Gene description for Akr1d1
Gene name aldo-keto reductase family 1, member D1
Gene symbol Akr1d1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Akr1d1
ExoCarta ExoCarta_192242
Vesiclepedia VP_192242
Entrez Gene 192242
UniProt P31210  
 Akr1d1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Akr1d1
Molecular Function
    aldose reductase (NADPH) activity GO:0004032 IBA
    steroid dehydrogenase activity GO:0016229 IBA
    ketosteroid monooxygenase activity GO:0047086 IBA
    3-oxo-5-beta-steroid 4-dehydrogenase activity GO:0047568 IDA
    Delta4-3-oxosteroid 5beta-reductase activity GO:0047787 IEA
Biological Process
    bile acid biosynthetic process GO:0006699 IEA
    bile acid biosynthetic process GO:0006699 ISO
    bile acid biosynthetic process GO:0006699 ISO
    cholesterol catabolic process GO:0006707 IEA
    cholesterol catabolic process GO:0006707 ISO
    digestion GO:0007586 IEA
    digestion GO:0007586 ISO
    C21-steroid hormone metabolic process GO:0008207 IEA
    C21-steroid hormone metabolic process GO:0008207 ISO
    androgen metabolic process GO:0008209 IBA
    androgen metabolic process GO:0008209 IEA
    androgen metabolic process GO:0008209 ISO
    bile acid catabolic process GO:0030573 IEA
Subcellular Localization
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Akr1d1 in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Akr1d1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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