Gene description for Akr1c14
Gene name aldo-keto reductase family 1, member C14
Gene symbol Akr1c14
Other names/aliases Akr1c9
Species Rattus norvegicus
 Database cross references - Akr1c14
ExoCarta ExoCarta_191574
Vesiclepedia VP_191574
Entrez Gene 191574
UniProt P23457  
 Akr1c14 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Akr1c14
Molecular Function
    aldose reductase (NADPH) activity GO:0004032 IBA
    steroid dehydrogenase activity GO:0016229 IDA
    oxidoreductase activity GO:0016491 IEA
    bile acid binding GO:0032052 IBA
    androsterone dehydrogenase activity GO:0047023 IBA
    androsterone dehydrogenase (B-specific) activity GO:0047042 IEA
    ketosteroid monooxygenase activity GO:0047086 IBA
Biological Process
    prostaglandin metabolic process GO:0006693 IBA
    steroid metabolic process GO:0008202 TAS
    hippocampus development GO:0021766 IEP
    progesterone metabolic process GO:0042448 IBA
    daunorubicin metabolic process GO:0044597 IBA
    doxorubicin metabolic process GO:0044598 IBA
Subcellular Localization
    cytosol GO:0005829 IBA
 Experiment description of studies that identified Akr1c14 in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Akr1c14
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Akr1c14 is involved
No pathways found





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