Gene description for Ctsa
Gene name cathepsin A
Gene symbol Ctsa
Other names/aliases AU019505
PPCA
Ppgb
Species Mus musculus
 Database cross references - Ctsa
ExoCarta ExoCarta_19025
Vesiclepedia VP_19025
Entrez Gene 19025
UniProt P16675  
 Ctsa identified in sEVs derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Ctsa
Molecular Function
    serine-type carboxypeptidase activity GO:0004185 IBA
    serine-type carboxypeptidase activity GO:0004185 ISO
    serine-type carboxypeptidase activity GO:0004185 ISS
    protein binding GO:0005515 IPI
Biological Process
    proteolysis GO:0006508 ISO
    proteolysis GO:0006508 ISS
    regulation of protein stability GO:0031647 IMP
    regulation of protein stability GO:0031647 ISO
    regulation of protein stability GO:0031647 ISS
    negative regulation of chaperone-mediated autophagy GO:1904715 IMP
    negative regulation of chaperone-mediated autophagy GO:1904715 ISO
    negative regulation of chaperone-mediated autophagy GO:1904715 ISS
Subcellular Localization
    mitochondrion GO:0005739 HDA
    lysosome GO:0005764 IEA
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Ctsa in sEVs
1
Experiment ID 188
MISEV standards
EM
Biophysical techniques
GAPDH|UCHL1|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Ctsa
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Neu1  
Affinity Capture-Western Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here