Gene description for Pla2g1b
Gene name phospholipase A2, group IB, pancreas
Gene symbol Pla2g1b
Other names/aliases Pla2a
sPLA2IB
Species Mus musculus
 Database cross references - Pla2g1b
ExoCarta ExoCarta_18778
Vesiclepedia VP_18778
Entrez Gene 18778
UniProt Q9Z0Y2  
 Pla2g1b identified in sEVs derived from the following tissue/cell type
Basophilic leukemia cells 20424270    
 Gene ontology annotations for Pla2g1b
Molecular Function
    phospholipase A2 activity GO:0004623 IDA
    phospholipase A2 activity GO:0004623 ISO
    signaling receptor binding GO:0005102 IBA
    signaling receptor binding GO:0005102 IDA
    signaling receptor binding GO:0005102 ISO
    calcium ion binding GO:0005509 IBA
    calcium ion binding GO:0005509 IEA
    calcium ion binding GO:0005509 ISO
    phospholipid binding GO:0005543 IBA
    bile acid binding GO:0032052 ISS
    calcium-dependent phospholipase A2 activity GO:0047498 IBA
    calcium-dependent phospholipase A2 activity GO:0047498 ISO
    calcium-dependent phospholipase A2 activity GO:0047498 ISS
    calcium-independent phospholipase A2 activity GO:0047499 IEA
Biological Process
    innate immune response in mucosa GO:0002227 IEA
    innate immune response in mucosa GO:0002227 ISO
    fatty acid biosynthetic process GO:0006633 IEA
    fatty acid biosynthetic process GO:0006633 ISO
    phospholipid metabolic process GO:0006644 ISO
    positive regulation of cell population proliferation GO:0008284 ISO
    phospholipid catabolic process GO:0009395 TAS
    lipid catabolic process GO:0016042 ISO
    antibacterial humoral response GO:0019731 IEA
    antibacterial humoral response GO:0019731 ISO
    phosphatidylcholine metabolic process GO:0046470 IBA
    phosphatidylcholine metabolic process GO:0046470 IEA
    phosphatidylcholine metabolic process GO:0046470 ISO
    phosphatidylglycerol metabolic process GO:0046471 IBA
    phosphatidylglycerol metabolic process GO:0046471 ISO
    phosphatidylglycerol metabolic process GO:0046471 ISS
    positive regulation of fibroblast proliferation GO:0048146 IEA
    positive regulation of fibroblast proliferation GO:0048146 ISO
    arachidonate secretion GO:0050482 IEA
    defense response to Gram-positive bacterium GO:0050830 IEA
    defense response to Gram-positive bacterium GO:0050830 ISO
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IEA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 ISO
    positive regulation of podocyte apoptotic process GO:1904635 ISO
    positive regulation of podocyte apoptotic process GO:1904635 ISS
Subcellular Localization
    extracellular region GO:0005576 IDA
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IEA
    extracellular space GO:0005615 ISO
    cell surface GO:0009986 IEA
    cell surface GO:0009986 ISO
    secretory granule GO:0030141 ISO
 Experiment description of studies that identified Pla2g1b in sEVs
1
Experiment ID 89
MISEV standards
EM
Biophysical techniques
Enriched markers
Negative markers
DLS
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 20424270    
Organism Rattus norvegicus
Experiment description Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.
Authors "Subra C, Grand D, Laulagnier K, Stella A, Lambeau G, Paillasse M, De Medina P, Monsarrat B, Perret B, Silvente-Poirot S, Poirot M, Record M."
Journal name JLR
Publication year 2010
Sample Basophilic leukemia cells
Sample name RBL-2H3
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Gas chromatography
Thin layer chromatography
Mass spectrometry [Qstar XL]
FACS
 Protein-protein interactions for Pla2g1b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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