Gene description for Pitpna
Gene name phosphatidylinositol transfer protein, alpha
Gene symbol Pitpna
Other names/aliases Pitpn
vb
vibrator
Species Mus musculus
 Database cross references - Pitpna
ExoCarta ExoCarta_18738
Vesiclepedia VP_18738
Entrez Gene 18738
UniProt P53810  
 Pitpna identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Pitpna
Molecular Function
    fatty-acyl-CoA binding GO:0000062 ISO
    phospholipid binding GO:0005543 ISO
    lipid binding GO:0008289 ISO
    lipid binding GO:0008289 ISS
    phosphatidylcholine transporter activity GO:0008525 IBA
    phosphatidylcholine transporter activity GO:0008525 ISO
    phosphatidylinositol transfer activity GO:0008526 IBA
    phosphatidylinositol transfer activity GO:0008526 IDA
    phosphatidylinositol transfer activity GO:0008526 ISO
    phosphatidylcholine binding GO:0031210 IBA
    phosphatidylcholine binding GO:0031210 IDA
    phosphatidylcholine binding GO:0031210 ISO
    phosphatidylinositol binding GO:0035091 IBA
    phosphatidylinositol binding GO:0035091 IDA
    phosphatidylinositol binding GO:0035091 ISO
    stearic acid binding GO:0070540 ISO
    phosphatidylcholine transfer activity GO:0120019 IDA
    phosphatidylcholine transfer activity GO:0120019 ISO
Biological Process
    axonogenesis GO:0007409 IMP
    phospholipid transport GO:0015914 IEA
    phospholipid transport GO:0015914 ISO
    intermembrane lipid transfer GO:0120009 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    membrane GO:0016020 ISS
    myelin sheath GO:0043209 HDA
 Experiment description of studies that identified Pitpna in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Pitpna
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ncapd2 68298
Co-fractionation Mus musculus
2 Sirt3  
Co-fractionation Mus musculus
3 Sstr3  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Pitpna is involved
No pathways found





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