Gene description for Abcb1b
Gene name ATP-binding cassette, sub-family B (MDR/TAP), member 1B
Gene symbol Abcb1b
Other names/aliases Abcb1
Mdr1
Mdr1b
Pgy-1
Pgy1
mdr
Species Mus musculus
 Database cross references - Abcb1b
ExoCarta ExoCarta_18669
Entrez Gene 18669
UniProt P06795  
 Abcb1b identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Abcb1b
Molecular Function
    drug transmembrane transporter activity GO:0015238 ISO
    xenobiotic-transporting ATPase activity GO:0008559 IEA
    ATPase activity, coupled to transmembrane movement of substances GO:0042626 IBA
    nucleotide binding GO:0000166 IEA
    transporter activity GO:0005215 ISO
    hydrolase activity GO:0016787 IEA
    ATP binding GO:0005524 IEA
    ATPase activity GO:0016887 IEA
Biological Process
    establishment of endothelial blood-brain barrier GO:0014045 ISO
    drug transport GO:0015893 ISO
    drug transmembrane transport GO:0006855 ISO
    transmembrane transport GO:0055085 IBA
    transport GO:0006810 ISO
    response to drug GO:0042493 ISO
Subcellular Localization
    mitochondrion GO:0005739 IDA
    Golgi membrane GO:0000139 ISO
    intercellular canaliculus GO:0046581 IDA
    apical plasma membrane GO:0016324 ISO
    integral component of membrane GO:0016021 IBA
    membrane GO:0016020 ISO
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified Abcb1b in exosomes
1
Experiment ID 214
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Abcb1b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Abcb1b is involved
PathwayEvidenceSource
ABC-family proteins mediated transport IEA Reactome





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