Gene description for Pax8
Gene name paired box 8
Gene symbol Pax8
Other names/aliases Pax-8
Species Mus musculus
 Database cross references - Pax8
ExoCarta ExoCarta_18510
Vesiclepedia VP_18510
Entrez Gene 18510
UniProt Q00288  
 Pax8 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Pax8
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    transcription cis-regulatory region binding GO:0000976 ISO
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISO
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISS
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IEA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 ISO
    DNA binding GO:0003677 ISO
    DNA binding GO:0003677 ISS
    DNA-binding transcription factor activity GO:0003700 ISO
    DNA-binding transcription factor activity GO:0003700 ISS
    DNA-binding transcription factor activity GO:0003700 TAS
    protein binding GO:0005515 IPI
    sequence-specific DNA binding GO:0043565 ISO
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    urogenital system development GO:0001655 IGI
    metanephros development GO:0001656 IEP
    metanephros development GO:0001656 IGI
    branching involved in ureteric bud morphogenesis GO:0001658 IEA
    mesonephros development GO:0001823 IEP
    mesonephros development GO:0001823 IMP
    ventricular septum development GO:0003281 IMP
    mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 IEA
    DNA-templated transcription GO:0006351 IEA
    DNA-templated transcription GO:0006351 ISO
    regulation of DNA-templated transcription GO:0006355 ISO
    regulation of DNA-templated transcription GO:0006355 TAS
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    sulfur compound metabolic process GO:0006790 IEA
    nervous system development GO:0007399 IBA
    central nervous system development GO:0007417 IEP
    sensory organ development GO:0007423 IBA
    animal organ morphogenesis GO:0009887 TAS
    negative regulation of cardiac muscle cell apoptotic process GO:0010667 IMP
    epithelial cell differentiation GO:0030855 IMP
    thyroid gland development GO:0030878 IEP
    thyroid gland development GO:0030878 IGI
    thyroid gland development GO:0030878 IMP
    thyroid gland development GO:0030878 ISO
    pronephric field specification GO:0039003 IEP
    inner ear morphogenesis GO:0042472 IGI
    regulation of apoptotic process GO:0042981 IMP
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of DNA-templated transcription GO:0045893 IGI
    positive regulation of DNA-templated transcription GO:0045893 IMP
    positive regulation of DNA-templated transcription GO:0045893 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    pronephros development GO:0048793 IMP
    cellular response to gonadotropin stimulus GO:0071371 IEA
    cellular response to gonadotropin stimulus GO:0071371 ISO
    otic vesicle development GO:0071599 IEA
    S-shaped body morphogenesis GO:0072050 IEP
    kidney epithelium development GO:0072073 IEP
    positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 IMP
    mesonephric tubule development GO:0072164 IEP
    metanephric distal convoluted tubule development GO:0072221 IMP
    metanephric comma-shaped body morphogenesis GO:0072278 IEA
    metanephric S-shaped body morphogenesis GO:0072284 IEA
    metanephric nephron tubule formation GO:0072289 IMP
    negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 IMP
    regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 IMP
    positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 IMP
    negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 IMP
    negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 IMP
    negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 IMP
    positive regulation of metanephric DCT cell differentiation GO:2000594 IMP
    positive regulation of thyroid hormone generation GO:2000611 IMP
    positive regulation of thyroid hormone generation GO:2000611 ISO
    regulation of thyroid-stimulating hormone secretion GO:2000612 ISO
    regulation of thyroid-stimulating hormone secretion GO:2000612 ISS
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    nucleoplasm GO:0005654 ISS
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 TAS
 Experiment description of studies that identified Pax8 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Pax8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atg12  
Negative Genetic Mus musculus
2 Rb1  
Co-fractionation Mus musculus
3 Jade1  
Two-hybrid Mus musculus
4 Nkx2-1  
Two-hybrid Mus musculus
View the network image/svg+xml
 Pathways in which Pax8 is involved
No pathways found





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