Gene description for Nudc
Gene name nuclear distribution gene C homolog (Aspergillus)
Gene symbol Nudc
Other names/aliases SIG-92
Silg92
Species Mus musculus
 Database cross references - Nudc
ExoCarta ExoCarta_18221
Vesiclepedia VP_18221
Entrez Gene 18221
UniProt O35685  
 Nudc identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Nudc
Molecular Function
    protein binding GO:0005515 IPI
    unfolded protein binding GO:0051082 IBA
Biological Process
    protein folding GO:0006457 IBA
    mitotic spindle organization GO:0007052 ISO
    mitotic spindle organization GO:0007052 ISS
    mitotic metaphase chromosome alignment GO:0007080 ISO
    mitotic metaphase chromosome alignment GO:0007080 ISS
    nuclear migration GO:0007097 IEA
    nuclear migration GO:0007097 ISO
    response to peptide hormone GO:0043434 IEA
    cell division GO:0051301 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    microtubule GO:0005874 IEA
    midbody GO:0030496 ISO
    midbody GO:0030496 ISS
    mitotic spindle GO:0072686 ISO
    mitotic spindle GO:0072686 ISS
 Experiment description of studies that identified Nudc in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Nudc
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tmem173  
Proximity Label-MS Mus musculus
2 Tars 110960
Co-fractionation Mus musculus
3 Tln1 21894
Co-fractionation Mus musculus
4 Dync1h1 13424
Affinity Capture-Western Mus musculus
5 Traf3  
Proximity Label-MS Mus musculus
6 Wipi2 74781
Co-fractionation Mus musculus
7 Pou5f1  
Affinity Capture-MS Mus musculus
8 Vps29 56433
Co-fractionation Mus musculus
9 Rps17 20068
Co-fractionation Mus musculus
10 Kcnma1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here