Gene description for Usp34
Gene name ubiquitin specific peptidase 34
Gene symbol Usp34
Other names/aliases A530081C03Rik
Murr2
Species Mus musculus
 Database cross references - Usp34
ExoCarta ExoCarta_17847
Entrez Gene 17847
UniProt Q6ZQ93  
 Usp34 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Usp34
Molecular Function
    cysteine-type endopeptidase activity GO:0004197 ISO
    cysteine-type peptidase activity GO:0008234 IEA
    ubiquitinyl hydrolase activity GO:0036459 IEA
    hydrolase activity GO:0016787 IEA
    peptidase activity GO:0008233 IEA
    ubiquitin-specific protease activity GO:0004843 ISO
Biological Process
    Wnt signaling pathway GO:0016055 IEA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IBA
    protein K48-linked deubiquitination GO:0071108 ISO
    proteolysis GO:0006508 IEA
    positive regulation of canonical Wnt signaling pathway GO:0090263 ISO
    ubiquitin-dependent protein catabolic process GO:0006511 IEA
    regulation of proteasomal protein catabolic process GO:0061136 IBA
    protein deubiquitination GO:0016579 ISO
Subcellular Localization
    cellular_component GO:0005575 ND
    cytoplasm GO:0005737 IBA
    nucleus GO:0005634 IBA
 Experiment description of studies that identified Usp34 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Usp34
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Usp34 is involved
PathwayEvidenceSource
TCF dependent signaling in response to WNT IEA Reactome





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