Gene description for Mtf1
Gene name metal response element binding transcription factor 1
Gene symbol Mtf1
Other names/aliases MTF-1
Thyls
Species Mus musculus
 Database cross references - Mtf1
ExoCarta ExoCarta_17764
Vesiclepedia VP_17764
Entrez Gene 17764
UniProt Q07243  
 Mtf1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Mtf1
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 ISO
    cis-regulatory region sequence-specific DNA binding GO:0000987 IDA
    cis-regulatory region sequence-specific DNA binding GO:0000987 ISO
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IBA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IEA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 ISO
    DNA-binding transcription factor activity GO:0003700 IDA
    histone acetyltransferase binding GO:0035035 IPI
    metal ion binding GO:0046872 IEA
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    DNA-templated transcription GO:0006351 IDA
    response to oxidative stress GO:0006979 IMP
    central nervous system development GO:0007417 IBA
    positive regulation of DNA-templated transcription GO:0045893 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    response to cadmium ion GO:0046686 IMP
    cellular response to zinc ion GO:0071294 IDA
    cartilage homeostasis GO:1990079 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IC
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 ISO
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified Mtf1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Mtf1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Nr4a3  
Two-hybrid Mus musculus
2 Rnf14  
Two-hybrid Mus musculus
3 Tmem173  
Proximity Label-MS Mus musculus
4 Cers2  
Two-hybrid Mus musculus
View the network image/svg+xml
 Pathways in which Mtf1 is involved
No pathways found





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