Gene description for Meis1
Gene name Meis homeobox 1
Gene symbol Meis1
Other names/aliases C530044H18Rik
Evi8
Species Mus musculus
 Database cross references - Meis1
ExoCarta ExoCarta_17268
Vesiclepedia VP_17268
Entrez Gene 17268
UniProt Q60954  
 Meis1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Meis1
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IBA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    DNA binding GO:0003677 IDA
    DNA binding GO:0003677 ISO
    chromatin binding GO:0003682 IDA
    protein binding GO:0005515 IPI
    sequence-specific DNA binding GO:0043565 IDA
    sequence-specific DNA binding GO:0043565 IGI
Biological Process
    angiogenesis GO:0001525 IBA
    angiogenesis GO:0001525 IMP
    eye development GO:0001654 IBA
    lens morphogenesis in camera-type eye GO:0002089 IMP
    regulation of DNA-templated transcription GO:0006355 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IC
    brain development GO:0007420 IBA
    locomotory behavior GO:0007626 IMP
    positive regulation of cell population proliferation GO:0008284 IBA
    embryonic pattern specification GO:0009880 IBA
    animal organ morphogenesis GO:0009887 IBA
    hemopoiesis GO:0030097 IBA
    hemopoiesis GO:0030097 IMP
    megakaryocyte development GO:0035855 IMP
    negative regulation of myeloid cell differentiation GO:0045638 IDA
    negative regulation of neuron differentiation GO:0045665 IGI
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    blood vessel morphogenesis GO:0048514 IMP
    definitive hemopoiesis GO:0060216 IMP
    cell growth involved in cardiac muscle cell development GO:0061049 IEA
    cell growth involved in cardiac muscle cell development GO:0061049 ISO
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 IDA
 Experiment description of studies that identified Meis1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Meis1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Pbx2  
Two-hybrid Mus musculus
2 Pbx4  
Two-hybrid Mus musculus
3 Hoxa13  
Two-hybrid Mus musculus
4 Tlx1  
Two-hybrid Mus musculus
5 Hoxa11  
Two-hybrid Mus musculus
6 Pknox1  
Two-hybrid Mus musculus
7 Pdx1  
Affinity Capture-Western Mus musculus
8 Hoxd13  
Two-hybrid Mus musculus
9 Hoxa9  
Two-hybrid Mus musculus
10 Pbx1  
Affinity Capture-Western Mus musculus
11 Pbx3  
Two-hybrid Mus musculus
View the network image/svg+xml
 Pathways in which Meis1 is involved
No pathways found





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