Gene description for Mxd4
Gene name Max dimerization protein 4
Gene symbol Mxd4
Other names/aliases 2810410A03Rik
Mad4
bHLHc12
Species Mus musculus
 Database cross references - Mxd4
ExoCarta ExoCarta_17122
Vesiclepedia VP_17122
Entrez Gene 17122
 Mxd4 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Mxd4
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IMP
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IMP
    DNA binding GO:0003677 IDA
    protein binding GO:0005515 IPI
    protein dimerization activity GO:0046983 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    negative regulation of DNA-templated transcription GO:0045892 IGI
Subcellular Localization
    RNA polymerase II transcription regulator complex GO:0090575 IMP
 Experiment description of studies that identified Mxd4 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Mxd4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Max  
Two-hybrid Mus musculus
View the network image/svg+xml
 Pathways in which Mxd4 is involved
No pathways found





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