Gene description for Gbp2
Gene name guanylate binding protein 2, interferon-inducible
Gene symbol Gbp2
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Gbp2
ExoCarta ExoCarta_171164
Vesiclepedia VP_171164
Entrez Gene 171164
UniProt Q63663  
 Gbp2 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Gbp2
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 IEA
    endopeptidase inhibitor activity GO:0004866 IEA
    endopeptidase inhibitor activity GO:0004866 ISO
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 IEA
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
    molecular function inhibitor activity GO:0140678 ISO
    membrane scission GTPase motor activity GO:1990606 IEA
Biological Process
    activation of innate immune response GO:0002218 IEA
    activation of innate immune response GO:0002218 ISO
    activation of innate immune response GO:0002218 ISS
    protein targeting GO:0006605 IEA
    protein targeting GO:0006605 ISO
    response to bacterium GO:0009617 ISO
    protein localization to nucleus GO:0034504 IEA
    protein localization to nucleus GO:0034504 ISO
    cellular response to interferon-beta GO:0035458 IEA
    cellular response to interferon-beta GO:0035458 ISO
    cellular response to interferon-beta GO:0035458 ISO
    defense response to bacterium GO:0042742 ISO
    defense response to bacterium GO:0042742 ISS
    defense response to protozoan GO:0042832 IBA
    defense response to protozoan GO:0042832 IEA
    defense response to protozoan GO:0042832 ISO
    adhesion of symbiont to host GO:0044406 IEA
    adhesion of symbiont to host GO:0044406 ISO
    defense response to Gram-positive bacterium GO:0050830 IBA
    defense response to Gram-positive bacterium GO:0050830 IEA
    defense response to Gram-positive bacterium GO:0050830 ISO
    defense response to virus GO:0051607 IEA
    defense response to virus GO:0051607 ISO
    defense response to virus GO:0051607 ISS
    cytolysis in another organism GO:0051715 IEA
    cytolysis in another organism GO:0051715 ISO
    cytolysis in another organism GO:0051715 ISS
    cellular response to lipopolysaccharide GO:0071222 IEA
    cellular response to lipopolysaccharide GO:0071222 ISO
    cellular response to lipopolysaccharide GO:0071222 ISO
    cellular response to lipopolysaccharide GO:0071222 ISS
    cellular response to type II interferon GO:0071346 IBA
    cellular response to type II interferon GO:0071346 IEA
    cellular response to type II interferon GO:0071346 ISO
    cellular response to type II interferon GO:0071346 ISO
    cellular response to interleukin-1 GO:0071347 IEA
    cellular response to interleukin-1 GO:0071347 ISO
    cellular response to tumor necrosis factor GO:0071356 IEA
    cellular response to tumor necrosis factor GO:0071356 ISO
    positive regulation of pyroptotic inflammatory response GO:0140639 IEA
    positive regulation of pyroptotic inflammatory response GO:0140639 ISO
    positive regulation of pyroptotic inflammatory response GO:0140639 ISS
    positive regulation of AIM2 inflammasome complex assembly GO:0140973 IEA
    positive regulation of AIM2 inflammasome complex assembly GO:0140973 ISO
    positive regulation of AIM2 inflammasome complex assembly GO:0140973 ISS
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    Golgi membrane GO:0000139 ISO
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    Golgi apparatus GO:0005794 ISO
    Golgi apparatus GO:0005794 ISO
    Golgi apparatus GO:0005794 ISS
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    cytoplasmic vesicle membrane GO:0030659 IEA
    cytoplasmic vesicle GO:0031410 IBA
    cytoplasmic vesicle GO:0031410 IEA
    cytoplasmic vesicle GO:0031410 ISO
    cytoplasmic vesicle GO:0031410 ISS
    perinuclear region of cytoplasm GO:0048471 IEA
    perinuclear region of cytoplasm GO:0048471 ISO
    symbiont cell surface GO:0106139 IEA
    symbiont cell surface GO:0106139 ISO
 Experiment description of studies that identified Gbp2 in sEVs
1
Experiment ID 92
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Gbp2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sumo3  
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml
 Pathways in which Gbp2 is involved
No pathways found





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