Gene description for Ilk
Gene name	integrin-linked kinase
Gene symbol	Ilk
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Ilk
ExoCarta	ExoCarta_170922
Vesiclepedia	VP_170922
Entrez Gene	170922
UniProt	Q99J82
Ilk identified in sEVs derived from the following tissue/cell type
Adipocytes	25998041
Reticulocytes	21828046

Gene ontology annotations for Ilk

Molecular Function     magnesium ion binding GO:0000287 IEA     magnesium ion binding GO:0000287 ISO     magnesium ion binding GO:0000287 ISS     protein kinase activity GO:0004672 IDA     protein serine/threonine kinase activity GO:0004674 IEA     protein serine/threonine kinase activity GO:0004674 ISO     protein serine/threonine kinase activity GO:0004674 ISS     signaling receptor binding GO:0005102 IBA     integrin binding GO:0005178 IEA     integrin binding GO:0005178 IPI     integrin binding GO:0005178 ISO     ATP binding GO:0005524 IEA     ATP binding GO:0005524 ISO     ATP binding GO:0005524 ISS     SH3 domain binding GO:0017124 IDA     protein kinase binding GO:0019901 IEA     protein kinase binding GO:0019901 ISO     protein domain specific binding GO:0019904 IC     protein domain specific binding GO:0019904 IDA     protein-macromolecule adaptor activity GO:0030674 IBA     protein-containing complex binding GO:0044877 IDA     protein-containing complex binding GO:0044877 IPI Biological Process     cell morphogenesis GO:0000902 IEA     cell morphogenesis GO:0000902 ISO     regulation of cell growth GO:0001558 IMP     branching involved in ureteric bud morphogenesis GO:0001658 IEA     branching involved in ureteric bud morphogenesis GO:0001658 ISO     positive regulation of cell-matrix adhesion GO:0001954 IMP     outflow tract morphogenesis GO:0003151 IEA     outflow tract morphogenesis GO:0003151 ISO     protein phosphorylation GO:0006468 IDA     negative regulation of protein kinase activity GO:0006469 IMP     mitotic spindle organization GO:0007052 IEA     mitotic spindle organization GO:0007052 ISO     mitotic spindle organization GO:0007052 ISS     cell-matrix adhesion GO:0007160 IBA     integrin-mediated signaling pathway GO:0007229 IBA     integrin-mediated signaling pathway GO:0007229 IEA     integrin-mediated signaling pathway GO:0007229 IMP     integrin-mediated signaling pathway GO:0007229 ISO     cell population proliferation GO:0008283 ISO     positive regulation of cell population proliferation GO:0008284 IEA     positive regulation of cell population proliferation GO:0008284 IMP     positive regulation of cell population proliferation GO:0008284 ISO     positive regulation of signal transduction GO:0009967 ISO     negative regulation of cardiac muscle cell apoptotic process GO:0010667 IMP     fibroblast migration GO:0010761 IEA     fibroblast migration GO:0010761 ISO     Schwann cell development GO:0014044 ISO     negative regulation of smooth muscle cell migration GO:0014912 IMP     peptidyl-serine phosphorylation GO:0018105 ISO     nerve development GO:0021675 IEA     nerve development GO:0021675 ISO     myelination in peripheral nervous system GO:0022011 IEA     myelination in peripheral nervous system GO:0022011 ISO     cell projection organization GO:0030030 IEA     cell projection organization GO:0030030 ISO     cell differentiation GO:0030154 IBA     positive regulation of cell migration GO:0030335 IMP     positive regulation of BMP signaling pathway GO:0030513 IEA     positive regulation of BMP signaling pathway GO:0030513 ISO     regulation of actin cytoskeleton organization GO:0032956 IMP     tumor necrosis factor-mediated signaling pathway GO:0033209 IEA     tumor necrosis factor-mediated signaling pathway GO:0033209 ISO     substrate adhesion-dependent cell spreading GO:0034446 IBA     substrate adhesion-dependent cell spreading GO:0034446 IEA     substrate adhesion-dependent cell spreading GO:0034446 IMP     substrate adhesion-dependent cell spreading GO:0034446 ISO     negative regulation of apoptotic process GO:0043066 IMP     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO     positive regulation of MAP kinase activity GO:0043406 IMP     positive regulation of MAPK cascade GO:0043410 IMP     phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IEA     phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 ISO     negative regulation of neuron apoptotic process GO:0043524 IMP     establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 IEA     establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 ISO     positive regulation of myoblast differentiation GO:0045663 IMP     positive regulation of osteoblast differentiation GO:0045669 IEA     positive regulation of osteoblast differentiation GO:0045669 ISO     positive regulation of axon extension GO:0045773 IMP     positive regulation of DNA-templated transcription GO:0045893 IEA     positive regulation of DNA-templated transcription GO:0045893 ISO     negative regulation of smooth muscle cell proliferation GO:0048662 IMP     neuron projection morphogenesis GO:0048812 IMP     positive regulation of axonogenesis GO:0050772 IMP     positive regulation of dendrite morphogenesis GO:0050775 IMP     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IMP     neural precursor cell proliferation GO:0061351 IEA     neural precursor cell proliferation GO:0061351 ISO     platelet aggregation GO:0070527 ISO     caveola assembly GO:0070836 IEA     caveola assembly GO:0070836 ISO     caveola assembly GO:0070836 ISS     protein localization to cell cortex GO:0072697 IEA     protein localization to cell cortex GO:0072697 ISO     protein localization to cell cortex GO:0072697 ISS     positive regulation of canonical Wnt signaling pathway GO:0090263 IEA     positive regulation of canonical Wnt signaling pathway GO:0090263 ISO     supramolecular fiber organization GO:0097435 IMP     positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IEA     positive regulation of substrate adhesion-dependent cell spreading GO:1900026 ISO     negative regulation of neural precursor cell proliferation GO:2000178 IEA     negative regulation of neural precursor cell proliferation GO:2000178 ISO     positive regulation of cellular senescence GO:2000774 IMP Subcellular Localization     chromatin GO:0000785 IEA     chromatin GO:0000785 ISO     chromatin GO:0000785 ISS     stress fiber GO:0001725 IDA     nucleus GO:0005634 IEA     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     centrosome GO:0005813 IEA     centrosome GO:0005813 ISO     centrosome GO:0005813 ISS     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     plasma membrane GO:0005886 IEA     cell-cell junction GO:0005911 IDA     focal adhesion GO:0005925 IBA     focal adhesion GO:0005925 IDA     focal adhesion GO:0005925 IEA     focal adhesion GO:0005925 ISO     cell cortex GO:0005938 IEA     sarcomere GO:0030017 IEA     lamellipodium GO:0030027 IEA     lamellipodium GO:0030027 ISO     axon GO:0030424 IDA     protein-containing complex GO:0032991 IDA     neuronal cell body GO:0043025 IDA     costamere GO:0043034 IDA     terminal bouton GO:0043195 IDA     dendritic shaft GO:0043198 IDA