Gene description for Snx18
Gene name sorting nexin 18
Gene symbol Snx18
Other names/aliases Snag1
Species Mus musculus
 Database cross references - Snx18
ExoCarta ExoCarta_170625
Vesiclepedia VP_170625
Entrez Gene 170625
 Snx18 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Snx18
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 ISO
    phosphatidylinositol binding GO:0035091 IBA
    phosphatidylinositol binding GO:0035091 IDA
Biological Process
    mitotic cell cycle GO:0000278 IEA
    mitotic cytokinesis GO:0000281 ISO
    endocytosis GO:0006897 IBA
    endocytosis GO:0006897 ISO
    endocytosis GO:0006897 ISS
    protein transport GO:0015031 ISO
    protein transport GO:0015031 ISS
    endosomal transport GO:0016197 IBA
    endosomal transport GO:0016197 ISO
    cleavage furrow formation GO:0036089 IBA
    cleavage furrow formation GO:0036089 ISO
    positive regulation of GTPase activity GO:0043547 ISO
    positive regulation of GTPase activity GO:0043547 ISS
    cell division GO:0051301 IEA
    plasma membrane tubulation GO:0097320 IBA
    positive regulation of autophagosome assembly GO:2000786 ISO
    positive regulation of autophagosome assembly GO:2000786 ISS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    cytoplasmic side of plasma membrane GO:0009898 ISO
    cytoplasmic side of plasma membrane GO:0009898 ISS
    clathrin-coated vesicle GO:0030136 ISO
    clathrin-coated vesicle GO:0030136 ISS
    growth cone GO:0030426 IDA
    cytoplasmic vesicle GO:0031410 IBA
    cytoplasmic vesicle GO:0031410 ISO
    neuronal cell body GO:0043025 IDA
    recycling endosome membrane GO:0055038 ISO
    recycling endosome membrane GO:0055038 ISS
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Snx18 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Snx18
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Zbtb7b  
Affinity Capture-MS Mus musculus
2 Eed  
Affinity Capture-MS Mus musculus
3 Nlrp3  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Snx18 is involved
No pathways found





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