Gene description for Llgl1
Gene name lethal giant larvae homolog 1 (Drosophila)
Gene symbol Llgl1
Other names/aliases AI325176
Lgl1
Llglh
Mgl1
Species Mus musculus
 Database cross references - Llgl1
ExoCarta ExoCarta_16897
Vesiclepedia VP_16897
Entrez Gene 16897
UniProt Q80Y17  
 Llgl1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Llgl1
Molecular Function
    GTPase activator activity GO:0005096 IBA
    GTPase activator activity GO:0005096 ISO
    GTPase activator activity GO:0005096 ISS
    protein kinase binding GO:0019901 ISO
    small GTPase binding GO:0031267 ISO
    myosin II binding GO:0045159 IBA
Biological Process
    exocytosis GO:0006887 IEA
    Golgi to plasma membrane transport GO:0006893 IBA
    Golgi to plasma membrane transport GO:0006893 ISO
    Golgi to plasma membrane transport GO:0006893 ISS
    axonogenesis GO:0007409 ISO
    axonogenesis GO:0007409 ISS
    brain development GO:0007420 TAS
    regulation of Notch signaling pathway GO:0008593 IBA
    cortical actin cytoskeleton organization GO:0030866 IBA
    cortical actin cytoskeleton organization GO:0030866 ISO
    regulation of establishment or maintenance of cell polarity GO:0032878 IBA
    maintenance of apical/basal cell polarity GO:0035090 IMP
    establishment of spindle orientation GO:0051294 IBA
    protein-containing complex assembly GO:0065003 ISO
Subcellular Localization
    Golgi cis cisterna GO:0000137 ISO
    Golgi cis cisterna GO:0000137 ISS
    Golgi membrane GO:0000139 IEA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    cytoskeleton GO:0005856 IDA
    plasma membrane GO:0005886 IBA
    basolateral plasma membrane GO:0016323 IDA
    axon GO:0030424 ISO
    axon GO:0030424 ISS
    cortical actin cytoskeleton GO:0030864 IBA
    cortical actin cytoskeleton GO:0030864 ISO
    early endosome membrane GO:0031901 ISO
    early endosome membrane GO:0031901 ISS
    trans-Golgi network membrane GO:0032588 ISO
    trans-Golgi network membrane GO:0032588 ISS
    myelin sheath abaxonal region GO:0035748 IDA
 Experiment description of studies that identified Llgl1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Llgl1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ubc  
Reconstituted Complex Mus musculus
2 Pars2  
Co-fractionation Mus musculus
3 Sstr3  
Proximity Label-MS Mus musculus
4 Tsr2  
Co-fractionation Mus musculus
5 Wdr11  
Co-fractionation Mus musculus
6 Abhd10  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Llgl1 is involved
No pathways found





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