Gene description for Lhx6
Gene name LIM homeobox protein 6
Gene symbol Lhx6
Other names/aliases Lhx6.1
Species Mus musculus
 Database cross references - Lhx6
ExoCarta ExoCarta_16874
Vesiclepedia VP_16874
Entrez Gene 16874
UniProt Q9R1R0  
 Lhx6 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Lhx6
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IEA
    DNA binding GO:0003677 IEA
    DNA-binding transcription factor activity GO:0003700 NAS
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    neuron migration GO:0001764 IMP
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    cerebral cortex radially oriented cell migration GO:0021799 IMP
    cerebral cortex tangential migration GO:0021800 IMP
    cerebral cortex GABAergic interneuron migration GO:0021853 IMP
    forebrain neuron fate commitment GO:0021877 IGI
    forebrain neuron development GO:0021884 IBA
    forebrain neuron development GO:0021884 IGI
    cerebral cortex neuron differentiation GO:0021895 IGI
    neuron differentiation GO:0030182 IBA
    neuron maturation GO:0042551 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Lhx6 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Lhx6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Usp7  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Lhx6 is involved
No pathways found





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