Gene description for Lef1
Gene name	lymphoid enhancer binding factor 1
Gene symbol	Lef1
Other names/aliases	3000002B05 AI451430 Lef-1
Species	Mus musculus
Database cross references - Lef1
ExoCarta	ExoCarta_16842
Entrez Gene	16842
UniProt	P27782
Lef1 identified in exosomes derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Lef1

Molecular Function     cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 ISO     estrogen receptor binding GO:0030331 ISO     protein binding GO:0005515 IPI     sequence-specific DNA binding transcription factor activity GO:0003700 ISO     RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity GO:0003705 IGI     C2H2 zinc finger domain binding GO:0070742 ISO     sequence-specific DNA binding GO:0043565 ISO     enhancer binding GO:0035326 ISO     chromatin binding GO:0003682 IDA     DNA binding GO:0003677 IDA     gamma-catenin binding GO:0045295 ISO     beta-catenin binding GO:0008013 ISO     DNA binding, bending GO:0008301 IDA     RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA     transcription regulatory region DNA binding GO:0044212 ISO     RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001228 ISO     transcription factor binding GO:0008134 IPI     RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IDA     histone binding GO:0042393 ISO     RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 ISO     armadillo repeat domain binding GO:0070016 ISO     estrogen receptor activity GO:0030284 ISO Biological Process     neural crest cell migration GO:0001755 IBA     negative regulation of interleukin-13 production GO:0032696 ISO     positive regulation of cell migration GO:0030335 ISO     forebrain radial glial cell differentiation GO:0021861 IGI     odontoblast differentiation GO:0071895 ISO     sprouting angiogenesis GO:0002040 IMP     muscle fiber development GO:0048747 IBA     trachea gland development GO:0061153 IMP     alpha-beta T cell differentiation GO:0046632 IGI     negative regulation of interleukin-5 production GO:0032714 ISO     negative regulation of canonical Wnt signaling pathway GO:0090090 ISO     negative regulation of transcription, DNA-templated GO:0045892 ISO     positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO     face morphogenesis GO:0060325 IGI     forebrain neuroblast division GO:0021873 IGI     negative regulation of DNA binding GO:0043392 ISO     B cell proliferation GO:0042100 IMP     epithelial to mesenchymal transition GO:0001837 IMP     negative regulation of interleukin-4 production GO:0032713 ISO     sensory perception of taste GO:0050909 IMP     eye pigmentation GO:0048069 IBA     T cell receptor V(D)J recombination GO:0033153 IGI     positive regulation of gene expression GO:0010628 ISO     cellular response to cytokine stimulus GO:0071345 ISO     palate development GO:0060021 IMP     BMP signaling pathway GO:0030509 IDA     hypothalamus development GO:0021854 IBA     negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 ISO     T-helper 1 cell differentiation GO:0045063 IDA     apoptotic process involved in morphogenesis GO:0060561 IMP     regulation of Wnt signaling pathway GO:0030111 IGI     cell development GO:0048468 IGI     embryonic limb morphogenesis GO:0030326 IGI     negative regulation of cell-cell adhesion GO:0022408 ISO     canonical Wnt signaling pathway GO:0060070 ISO     negative regulation of striated muscle tissue development GO:0045843 IDA     paraxial mesoderm formation GO:0048341 IGI     somitogenesis GO:0001756 IMP     generation of neurons GO:0048699 IBA     positive regulation of epithelial to mesenchymal transition GO:0010718 ISO     transcription, DNA-templated GO:0006351 IEA     histone H4 acetylation GO:0043967 ISO     positive regulation of cell proliferation GO:0008284 ISO     formation of radial glial scaffolds GO:0021943 IGI     odontogenesis of dentin-containing tooth GO:0042475 IMP     cellular response to interleukin-4 GO:0071353 ISO     vasculature development GO:0001944 IMP     positive regulation of cell growth GO:0030307 ISO     positive regulation of cell-cell adhesion GO:0022409 ISO     negative regulation of apoptotic process GO:0043066 ISO     apoptotic process involved in patterning of blood vessels GO:1902262 IMP     forebrain neuron differentiation GO:0021879 IBA     positive regulation by host of viral transcription GO:0043923 ISO     positive regulation of cell proliferation in bone marrow GO:0071864 ISO     histone H3 acetylation GO:0043966 ISO     regulation of transcription from RNA polymerase II promoter GO:0006357 IDA     regulation of cell-cell adhesion GO:0022407 IMP     dentate gyrus development GO:0021542 IMP     mammary gland development GO:0030879 IMP     transcription from RNA polymerase II promoter GO:0006366 ISO     patterning of blood vessels GO:0001569 IMP     osteoblast differentiation GO:0001649 IBA     positive regulation of granulocyte differentiation GO:0030854 ISO     anatomical structure regression GO:0060033 IMP     positive regulation of cell cycle process GO:0090068 ISO     neutrophil differentiation GO:0030223 ISO     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA     Wnt signaling pathway GO:0016055 ISO     positive regulation of transcription, DNA-templated GO:0045893 ISO     negative regulation of apoptotic process in bone marrow GO:0071866 ISO     hippocampus development GO:0021766 IMP     regulation of transcription, DNA-templated GO:0006355 IEA     chorio-allantoic fusion GO:0060710 IGI     negative regulation of estrogen receptor binding GO:0071899 ISO     tongue development GO:0043586 IMP     cell chemotaxis GO:0060326 ISO     steroid hormone mediated signaling pathway GO:0043401 ISO Subcellular Localization     nucleus GO:0005634 ISO     protein-DNA complex GO:0032993 ISO     transcription factor complex GO:0005667 ISO     cytoplasm GO:0005737 ISO