Gene description for Ldlr
Gene name low density lipoprotein receptor
Gene symbol Ldlr
Other names/aliases Hlb301
Species Mus musculus
 Database cross references - Ldlr
ExoCarta ExoCarta_16835
Vesiclepedia VP_16835
Entrez Gene 16835
UniProt P35951  
 Ldlr identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ldlr
Molecular Function
    amyloid-beta binding GO:0001540 IPI
    protease binding GO:0002020 IEA
    protease binding GO:0002020 ISO
    low-density lipoprotein particle receptor activity GO:0005041 IBA
    low-density lipoprotein particle receptor activity GO:0005041 IDA
    low-density lipoprotein particle receptor activity GO:0005041 IMP
    low-density lipoprotein particle receptor activity GO:0005041 ISO
    low-density lipoprotein particle receptor activity GO:0005041 TAS
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    low-density lipoprotein particle binding GO:0030169 IDA
    low-density lipoprotein particle binding GO:0030169 ISO
    very-low-density lipoprotein particle receptor activity GO:0030229 IDA
    very-low-density lipoprotein particle receptor activity GO:0030229 ISO
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    molecular adaptor activity GO:0060090 ISO
    lipoprotein particle binding GO:0071813 IBA
Biological Process
    retinoid metabolic process GO:0001523 IMP
    negative regulation of receptor recycling GO:0001920 ISO
    lipid metabolic process GO:0006629 IGI
    endocytosis GO:0006897 ISO
    receptor-mediated endocytosis GO:0006898 IDA
    phagocytosis GO:0006909 IDA
    long-term memory GO:0007616 IGI
    long-term memory GO:0007616 ISO
    cholesterol metabolic process GO:0008203 IMP
    positive regulation of gene expression GO:0010628 IGI
    positive regulation of gene expression GO:0010628 IMP
    negative regulation of gene expression GO:0010629 IMP
    positive regulation of triglyceride biosynthetic process GO:0010867 IMP
    positive regulation of triglyceride catabolic process GO:0010898 ISO
    regulation of phosphatidylcholine catabolic process GO:0010899 IMP
    negative regulation of low-density lipoprotein particle clearance GO:0010989 ISO
    phospholipid transport GO:0015914 IMP
    intestinal cholesterol absorption GO:0030299 IEA
    intestinal cholesterol absorption GO:0030299 ISO
    cholesterol transport GO:0030301 IMP
    cholesterol transport GO:0030301 ISO
    plasma lipoprotein particle clearance GO:0034381 IDA
    low-density lipoprotein particle clearance GO:0034383 IDA
    low-density lipoprotein particle clearance GO:0034383 IMP
    low-density lipoprotein particle clearance GO:0034383 ISO
    high-density lipoprotein particle clearance GO:0034384 IGI
    lipoprotein metabolic process GO:0042157 IGI
    lipoprotein catabolic process GO:0042159 IDA
    lipoprotein catabolic process GO:0042159 IMP
    cholesterol homeostasis GO:0042632 IBA
    cholesterol homeostasis GO:0042632 IGI
    cholesterol homeostasis GO:0042632 IGI
    cholesterol homeostasis GO:0042632 IMP
    cholesterol homeostasis GO:0042632 ISO
    artery morphogenesis GO:0048844 IMP
    positive regulation of inflammatory response GO:0050729 IGI
    regulation of protein metabolic process GO:0051246 IGI
    regulation of protein metabolic process GO:0051246 ISO
    negative regulation of protein metabolic process GO:0051248 IDA
    establishment of localization in cell GO:0051649 IMP
    response to caloric restriction GO:0061771 IGI
    response to caloric restriction GO:0061771 ISO
    negative regulation of astrocyte activation GO:0061889 IGI
    cholesterol import GO:0070508 IMP
    cholesterol import GO:0070508 ISO
    cellular response to fatty acid GO:0071398 IGI
    cellular response to low-density lipoprotein particle stimulus GO:0071404 IEA
    cellular response to low-density lipoprotein particle stimulus GO:0071404 ISO
    receptor-mediated endocytosis involved in cholesterol transport GO:0090118 IBA
    receptor-mediated endocytosis involved in cholesterol transport GO:0090118 IEA
    receptor-mediated endocytosis involved in cholesterol transport GO:0090118 ISO
    regulation of cholesterol metabolic process GO:0090181 IGI
    amyloid-beta clearance GO:0097242 IGI
    amyloid-beta clearance by cellular catabolic process GO:0150094 IDA
    negative regulation of microglial cell activation GO:1903979 IGI
    positive regulation of lysosomal protein catabolic process GO:1905167 IDA
    negative regulation of amyloid fibril formation GO:1905907 IGI
Subcellular Localization
    extracellular space GO:0005615 HDA
    lysosome GO:0005764 IDA
    lysosome GO:0005764 ISO
    lysosome GO:0005764 ISS
    endosome GO:0005768 IDA
    early endosome GO:0005769 IBA
    early endosome GO:0005769 IDA
    early endosome GO:0005769 ISO
    early endosome GO:0005769 ISS
    late endosome GO:0005770 IDA
    late endosome GO:0005770 ISO
    late endosome GO:0005770 ISS
    Golgi apparatus GO:0005794 ISO
    Golgi apparatus GO:0005794 ISS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IMP
    plasma membrane GO:0005886 TAS
    caveola GO:0005901 ISO
    clathrin-coated pit GO:0005905 IEA
    clathrin-coated pit GO:0005905 ISO
    external side of plasma membrane GO:0009897 IEA
    external side of plasma membrane GO:0009897 ISO
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
    cell surface GO:0009986 ISS
    basolateral plasma membrane GO:0016323 IDA
    low-density lipoprotein particle GO:0034362 IEA
    somatodendritic compartment GO:0036477 IDA
    receptor complex GO:0043235 ISO
    apical part of cell GO:0045177 IDA
    recycling endosome membrane GO:0055038 ISO
    sorting endosome GO:0097443 IDA
    PCSK9-LDLR complex GO:1990666 ISO
    PCSK9-LDLR complex GO:1990666 ISS
 Experiment description of studies that identified Ldlr in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ldlr
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Pdia5  
Co-fractionation Mus musculus
2 Mylip  
Co-fractionation Mus musculus
3 Flt1  
Affinity Capture-Western Mus musculus
4 Tmem38b  
Co-fractionation Mus musculus
5 Dab1  
Reconstituted Complex Mus musculus
6 Lrp8  
Co-fractionation Mus musculus
7 Vldlr  
Co-fractionation Mus musculus
8 Ngly1  
Co-fractionation Mus musculus
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