Gene description for Lamp1
Gene name lysosomal-associated membrane protein 1
Gene symbol Lamp1
Other names/aliases AI196048
CD107a
Lamp-1
Species Mus musculus
 Database cross references - Lamp1
ExoCarta ExoCarta_16783
Entrez Gene 16783
UniProt P11438  
 Lamp1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
Mammary adenocarcinoma cells 11231627    
Microglia 16081791    
 Gene ontology annotations for Lamp1
Molecular Function
    enzyme binding GO:0019899 ISO
    protein domain specific binding GO:0019904 IPI
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of natural killer cell degranulation GO:0043323 ISO
    establishment of protein localization to organelle GO:0072594 ISO
    positive regulation of natural killer cell mediated cytotoxicity GO:0045954 ISO
    spermatogenesis GO:0007283 TAS
    granzyme-mediated apoptotic signaling pathway GO:0008626 ISO
    autophagic cell death GO:0048102 ISO
    Golgi to lysosome transport GO:0090160 ISO
    regulation of organelle transport along microtubule GO:1902513 ISO
    protein stabilization GO:0050821 IMP
Subcellular Localization
    late endosome GO:0005770 ISO
    integral component of membrane GO:0016021 IEA
    cytoplasmic vesicle GO:0031410 ISO
    multivesicular body GO:0005771 ISO
    plasma membrane GO:0005886 ISO
    melanosome GO:0042470 IDA
    cytoplasm GO:0005737 ISO
    external side of plasma membrane GO:0009897 IDA
    vacuole GO:0005773 ISO
    sarcolemma GO:0042383 IDA
    alveolar lamellar body GO:0097208 ISO
    endosome GO:0005768 IDA
    synaptic vesicle GO:0008021 IDA
    phagolysosome membrane GO:0061474 IDA
    cytolytic granule GO:0044194 IDA
    extracellular exosome GO:0070062 ISO
    lysosome GO:0005764 ISO
    neuronal cell body GO:0043025 ISO
    vesicle GO:0031982 IDA
    membrane GO:0016020 ISO
    cell surface GO:0009986 IDA
    dendrite GO:0030425 ISO
 Experiment description of studies that identified Lamp1 in exosomes
1
Experiment ID 210
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD81|FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 23
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
Immunoelectron Microscopy
PubMed ID 11231627    
Organism Mus musculus
Experiment description Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming.
Authors Wolfers J, Lozier A, Raposo G, Regnault A, Thery C, Masurier C, Flament C, Pouzieux S, Faure F, Tursz T, Angevin E, Amigorena S, Zitvogel L
Journal name NM
Publication year 2001
Sample Mammary adenocarcinoma cells
Sample name TS/A (H-2d)
P815 mastocytoma cells (H-2d)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Immunoelectron Microscopy
3
Experiment ID 14
ISEV standards
EM
EV Biophysical techniques
RAB7|RAB11
EV Cytosolic markers
CD9|CD63|LAMP1|LAMP2
EV Membrane markers
DNM
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
 Protein-protein interactions for Lamp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lamp1 is involved
No pathways found





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