Gene description for Klrd1
Gene name killer cell lectin-like receptor, subfamily D, member 1
Gene symbol Klrd1
Other names/aliases CD94
Species Mus musculus
 Database cross references - Klrd1
ExoCarta ExoCarta_16643
Vesiclepedia VP_16643
Entrez Gene 16643
UniProt O54707  
 Klrd1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Klrd1
Molecular Function
    transmembrane signaling receptor activity GO:0004888 IBA
    MHC class I protein complex binding GO:0023024 ISO
    MHC class Ib protein binding, via antigen binding groove GO:0023030 ISO
    carbohydrate binding GO:0030246 IEA
    HLA-E specific inhibitory MHC class Ib receptor activity GO:0062082 ISO
    protein antigen binding GO:1990405 ISO
Biological Process
    negative regulation of T cell mediated cytotoxicity GO:0001915 ISO
    negative regulation of T cell mediated cytotoxicity GO:0001915 ISS
    stimulatory C-type lectin receptor signaling pathway GO:0002223 IBA
    stimulatory C-type lectin receptor signaling pathway GO:0002223 ISO
    stimulatory C-type lectin receptor signaling pathway GO:0002223 ISS
    natural killer cell mediated immunity GO:0002228 ISO
    adaptive immune response GO:0002250 IEA
    regulation of natural killer cell activation GO:0032814 NAS
    innate immune response GO:0045087 IEA
    negative regulation of natural killer cell mediated cytotoxicity GO:0045953 ISO
    negative regulation of natural killer cell mediated cytotoxicity GO:0045953 ISS
    positive regulation of natural killer cell mediated cytotoxicity GO:0045954 IBA
    positive regulation of natural killer cell mediated cytotoxicity GO:0045954 ISO
Subcellular Localization
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    external side of plasma membrane GO:0009897 IBA
    external side of plasma membrane GO:0009897 IDA
    receptor complex GO:0043235 ISO
    receptor complex GO:0043235 ISS
 Experiment description of studies that identified Klrd1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Klrd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Klrd1 is involved
PathwayEvidenceSource
DAP12 interactions IEA Reactome
DAP12 signaling IEA Reactome
Immune System IEA Reactome
Innate Immune System IEA Reactome





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