Gene description for Napsa
Gene name napsin A aspartic peptidase
Gene symbol Napsa
Other names/aliases KAP
Kdap
NAP1
SNAPA
pronapsin
Species Mus musculus
 Database cross references - Napsa
ExoCarta ExoCarta_16541
Vesiclepedia VP_16541
Entrez Gene 16541
UniProt O09043  
 Napsa identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Napsa
Molecular Function
    endopeptidase activity GO:0004175 IMP
    endopeptidase activity GO:0004175 ISO
    aspartic-type endopeptidase activity GO:0004190 IBA
    aspartic-type endopeptidase activity GO:0004190 IEA
    peptidase activity GO:0008233 ISO
Biological Process
    proteolysis GO:0006508 IBA
    membrane protein proteolysis GO:0033619 IMP
    membrane protein proteolysis GO:0033619 ISO
    surfactant homeostasis GO:0043129 IEA
    surfactant homeostasis GO:0043129 ISO
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IEA
    extracellular space GO:0005615 ISO
    lysosome GO:0005764 IBA
    lysosome GO:0005764 IDA
    lysosome GO:0005764 ISO
    alveolar lamellar body GO:0097208 IDA
    alveolar lamellar body GO:0097208 ISO
 Experiment description of studies that identified Napsa in sEVs
1
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Napsa
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Napsa is involved
PathwayEvidenceSource
Metabolism of proteins IEA Reactome
Surfactant metabolism IEA Reactome





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