Gene description for Jund
Gene name jun D proto-oncogene
Gene symbol Jund
Other names/aliases Jund1
Species Mus musculus
 Database cross references - Jund
ExoCarta ExoCarta_16478
Vesiclepedia VP_16478
Entrez Gene 16478
UniProt P15066  
 Jund identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Jund
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    transcription cis-regulatory region binding GO:0000976 ISO
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IMP
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    transcription coregulator binding GO:0001221 IPI
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IC
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IMP
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 ISO
    DNA binding GO:0003677 IDA
    double-stranded DNA binding GO:0003690 ISO
    DNA-binding transcription factor activity GO:0003700 ISO
    transcription coactivator activity GO:0003713 ISO
    protein binding GO:0005515 IPI
    nuclear receptor binding GO:0016922 ISO
    enzyme binding GO:0019899 IEA
    enzyme binding GO:0019899 ISO
    sequence-specific DNA binding GO:0043565 ISO
    sequence-specific double-stranded DNA binding GO:1990837 ISO
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISO
    osteoblast development GO:0002076 IGI
    regulation of DNA-templated transcription GO:0006355 ISO
    transcription by RNA polymerase II GO:0006366 ISO
    gene expression GO:0010467 IMP
    positive regulation of peroxisome proliferator activated receptor signaling pathway GO:0035360 ISO
    regulation of cell population proliferation GO:0042127 IBA
    positive regulation of macrophage activation GO:0043032 ISO
    positive regulation of osteoblast differentiation GO:0045669 IGI
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IGI
    positive regulation of transcription by RNA polymerase II GO:0045944 IGI
    positive regulation of transcription by RNA polymerase II GO:0045944 ISO
    response to steroid hormone GO:0048545 IBA
    regulation of cell cycle GO:0051726 IBA
    cellular response to calcium ion GO:0071277 IDA
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    transcription regulator complex GO:0005667 IBA
    transcription repressor complex GO:0017053 ISO
    protein-containing complex GO:0032991 ISO
    protein-DNA complex GO:0032993 ISO
    transcription factor AP-1 complex GO:0035976 IEA
    transcription factor AP-1 complex GO:0035976 ISO
    RNA polymerase II transcription regulator complex GO:0090575 ISO
 Experiment description of studies that identified Jund in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Jund
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Nfe2l2  
Affinity Capture-Western Mus musculus
2 Men1  
Affinity Capture-Western Mus musculus
3 Batf3  
Two-hybrid Mus musculus
4 Sirt1  
Affinity Capture-Western Mus musculus
5 Fos  
Reconstituted Complex Mus musculus
6 Fam175b  
Two-hybrid Mus musculus
View the network image/svg+xml
 Pathways in which Jund is involved
No pathways found





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