Gene description for Itpa
Gene name inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
Gene symbol Itpa
Other names/aliases 2010016I08Rik
AU020102
Itp
Species Mus musculus
 Database cross references - Itpa
ExoCarta ExoCarta_16434
Vesiclepedia VP_16434
Entrez Gene 16434
UniProt Q9D892  
 Itpa identified in sEVs derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Itpa
Molecular Function
    nucleotide binding GO:0000166 IEA
    dITP diphosphatase activity GO:0035870 IMP
    ITP diphosphatase activity GO:0036220 IEA
    XTP diphosphatase activity GO:0036222 IEA
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    metal ion binding GO:0046872 IEA
    nucleoside triphosphate diphosphatase activity GO:0047429 IBA
    nucleoside triphosphate diphosphatase activity GO:0047429 IDA
    8-oxo-(d)RTP hydrolase activity GO:0106379 IEA
Biological Process
    ITP catabolic process GO:0006193 IMP
    nucleoside triphosphate catabolic process GO:0009143 IBA
    deoxyribonucleoside triphosphate catabolic process GO:0009204 IEA
    chromosome organization GO:0051276 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Itpa in sEVs
1
Experiment ID 188
MISEV standards
EM
Biophysical techniques
GAPDH|UCHL1|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Itpa
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atxn1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Itpa is involved
PathwayEvidenceSource
Drug ADME IEA Reactome
Metabolism IEA Reactome
Metabolism of nucleotides IEA Reactome
Nucleotide catabolism IEA Reactome
Purine catabolism IEA Reactome
Ribavirin ADME IEA Reactome





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