Gene description for Itln1
Gene name intelectin 1 (galactofuranose binding)
Gene symbol Itln1
Other names/aliases IntL
Itln
Itln2
Itln5
Itlna
Lfr
Species Mus musculus
 Database cross references - Itln1
ExoCarta ExoCarta_16429
Vesiclepedia VP_16429
Entrez Gene 16429
UniProt O88310  
 Itln1 identified in sEVs derived from the following tissue/cell type
Faeces 33431899    
Faeces 33431899    
 Gene ontology annotations for Itln1
Molecular Function
    calcium ion binding GO:0005509 ISO
    calcium ion binding GO:0005509 ISS
    carbohydrate binding GO:0030246 ISS
    identical protein binding GO:0042802 ISO
    oligosaccharide binding GO:0070492 IBA
    oligosaccharide binding GO:0070492 IDA
    oligosaccharide binding GO:0070492 ISO
Biological Process
    positive regulation of protein phosphorylation GO:0001934 ISS
    response to nematode GO:0009624 IDA
    positive regulation of D-glucose import GO:0046326 ISS
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 IBA
    brush border membrane GO:0031526 IDA
    receptor complex GO:0043235 ISO
    membrane raft GO:0045121 IDA
    collagen-containing extracellular matrix GO:0062023 HDA
    side of membrane GO:0098552 IEA
 Experiment description of studies that identified Itln1 in sEVs
1
Experiment ID 303
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
2
Experiment ID 304
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
 Protein-protein interactions for Itln1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fitm2  
Negative Genetic Mus musculus
View the network image/svg+xml
 Pathways in which Itln1 is involved
PathwayEvidenceSource
Antimicrobial peptides IEA Reactome
Immune System IEA Reactome
Innate Immune System IEA Reactome





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