Gene description for Itgb6
Gene name integrin beta 6
Gene symbol Itgb6
Other names/aliases 2210409C20Rik
4831415H04Rik
Species Mus musculus
 Database cross references - Itgb6
ExoCarta ExoCarta_16420
Vesiclepedia VP_16420
Entrez Gene 16420
UniProt Q9Z0T9  
 Itgb6 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Itgb6
Molecular Function
    integrin binding GO:0005178 IBA
    integrin binding GO:0005178 IPI
    metal ion binding GO:0046872 IEA
    molecular function activator activity GO:0140677 IEA
Biological Process
    cell morphogenesis GO:0000902 IMP
    cytokine production involved in inflammatory response GO:0002534 IMP
    inflammatory response GO:0006954 IMP
    immune response GO:0006955 IGI
    cell-matrix adhesion GO:0007160 IBA
    cell-matrix adhesion GO:0007160 IMP
    transforming growth factor beta receptor signaling pathway GO:0007179 IGI
    transforming growth factor beta receptor signaling pathway GO:0007179 IMP
    integrin-mediated signaling pathway GO:0007229 IBA
    integrin-mediated signaling pathway GO:0007229 IEA
    response to wounding GO:0009611 IDA
    response to virus GO:0009615 IGI
    gene expression GO:0010467 IMP
    gene expression GO:0010467 IMP
    cell migration GO:0016477 IBA
    cell adhesion mediated by integrin GO:0033627 IBA
    cell adhesion mediated by integrin GO:0033627 IDA
    cell adhesion mediated by integrin GO:0033627 ISO
    cell adhesion mediated by integrin GO:0033627 ISS
    wound healing GO:0042060 IMP
    surfactant homeostasis GO:0043129 IMP
    skin development GO:0043588 IMP
    lung alveolus development GO:0048286 IDA
    lung alveolus development GO:0048286 IMP
    phospholipid homeostasis GO:0055091 IMP
    hard palate development GO:0060022 IGI
    bone development GO:0060348 IMP
    bronchiole development GO:0060435 IDA
    bronchiole development GO:0060435 IMP
    Langerhans cell differentiation GO:0061520 IGI
    enamel mineralization GO:0070166 IMP
    cellular response to ionizing radiation GO:0071479 IDA
    transforming growth factor beta production GO:0071604 IDA
    cell-cell adhesion GO:0098609 IBA
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    centrosome GO:0005813 IEA
    centrosome GO:0005813 ISO
    focal adhesion GO:0005925 IBA
    focal adhesion GO:0005925 ISO
    focal adhesion GO:0005925 ISS
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IDA
    cell junction GO:0030054 ISO
    integrin alphav-beta6 complex GO:0034685 IBA
    integrin alphav-beta6 complex GO:0034685 IDA
    integrin alphav-beta6 complex GO:0034685 ISO
    receptor complex GO:0043235 ISO
 Experiment description of studies that identified Itgb6 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Itgb6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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