Gene description for Itgal
Gene name integrin alpha L
Gene symbol Itgal
Other names/aliases (p180)
Cd11a
LFA-1
LFA-1A
Ly-15
Ly-21
Species Mus musculus
 Database cross references - Itgal
ExoCarta ExoCarta_16408
Vesiclepedia VP_16408
Entrez Gene 16408
 Itgal identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Itgal
Molecular Function
    integrin binding GO:0005178 IBA
    ICAM-3 receptor activity GO:0030369 ISO
    protein-containing complex binding GO:0044877 ISO
    metal ion binding GO:0046872 IEA
    cell adhesion molecule binding GO:0050839 ISO
Biological Process
    T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 ISO
    phagocytosis GO:0006909 IEA
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 ISO
    leukocyte cell-cell adhesion GO:0007159 IDA
    leukocyte cell-cell adhesion GO:0007159 IMP
    leukocyte cell-cell adhesion GO:0007159 ISO
    cell-matrix adhesion GO:0007160 IBA
    cell-matrix adhesion GO:0007160 ISO
    cell surface receptor signaling pathway GO:0007166 IDA
    integrin-mediated signaling pathway GO:0007229 IBA
    integrin-mediated signaling pathway GO:0007229 IEA
    calcium-mediated signaling GO:0019722 IDA
    regulation of cell-cell adhesion GO:0022407 IDA
    positive regulation of cell-cell adhesion GO:0022409 IMP
    cell adhesion mediated by integrin GO:0033627 IBA
    memory T cell extravasation GO:0035683 ISO
    positive regulation of T cell proliferation GO:0042102 IMP
    receptor clustering GO:0043113 ISO
    activated T cell proliferation GO:0050798 IMP
    positive regulation of calcium-mediated signaling GO:0050850 IDA
    cell-cell adhesion GO:0098609 IBA
    cell-cell adhesion GO:0098609 IGI
    cell-cell adhesion GO:0098609 ISO
Subcellular Localization
    immunological synapse GO:0001772 IDA
    cell-cell junction GO:0005911 IDA
    integrin complex GO:0008305 IBA
    integrin complex GO:0008305 IEA
    external side of plasma membrane GO:0009897 IBA
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 ISO
    integrin alphaL-beta2 complex GO:0034687 ISO
 Experiment description of studies that identified Itgal in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Itgal
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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