Gene description for Itga4
Gene name	integrin alpha 4
Gene symbol	Itga4
Other names/aliases	CD49D Itga4B
Species	Mus musculus
Database cross references - Itga4
ExoCarta	ExoCarta_16401
Vesiclepedia	VP_16401
Entrez Gene	16401
UniProt	Q00651
Itga4 identified in sEVs derived from the following tissue/cell type
Macrophages	23658846
Macrophages	23658846
Macrophages	23658846

Gene ontology annotations for Itga4

Molecular Function     fibronectin binding GO:0001968 IMP     fibronectin binding GO:0001968 ISO     antigen binding GO:0003823 ISO     integrin binding GO:0005178 IBA     C-X3-C chemokine binding GO:0019960 ISO     C-X3-C chemokine binding GO:0019960 ISS     metal ion binding GO:0046872 IEA     cell adhesion molecule binding GO:0050839 ISO     protein antigen binding GO:1990405 ISO Biological Process     blood vessel remodeling GO:0001974 IMP     positive regulation of leukocyte migration GO:0002687 ISO     cell-matrix adhesion involved in ameboidal cell migration GO:0003366 ISO     cell adhesion GO:0007155 IMP     heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IMP     leukocyte cell-cell adhesion GO:0007159 IMP     leukocyte cell-cell adhesion GO:0007159 ISO     leukocyte cell-cell adhesion GO:0007159 NAS     cell-matrix adhesion GO:0007160 IBA     cell-matrix adhesion GO:0007160 ISO     cell-matrix adhesion GO:0007160 NAS     cell-matrix adhesion GO:0007160 TAS     integrin-mediated signaling pathway GO:0007229 IBA     integrin-mediated signaling pathway GO:0007229 NAS     heart development GO:0007507 IMP     cell migration GO:0016477 IMP     cell adhesion mediated by integrin GO:0033627 IBA     cell-cell adhesion mediated by integrin GO:0033631 ISO     heterotypic cell-cell adhesion GO:0034113 ISO     substrate adhesion-dependent cell spreading GO:0034446 ISO     receptor clustering GO:0043113 ISO     negative regulation of vasoconstriction GO:0045906 ISO     negative regulation of vasoconstriction GO:0045906 ISS     leukocyte tethering or rolling GO:0050901 ISO     diapedesis GO:0050904 ISO     face development GO:0060324 IMP     axonogenesis involved in innervation GO:0060385 ISO     mesenchyme development GO:0060485 TAS     chorio-allantoic fusion GO:0060710 IMP     visceral serous pericardium development GO:0061032 TAS     T cell migration GO:0072678 IMP     negative regulation of protein homodimerization activity GO:0090074 ISO     negative regulation of protein homodimerization activity GO:0090074 ISS     cell-cell adhesion GO:0098609 IBA     cell-cell adhesion GO:0098609 TAS     import into cell GO:0098657 ISO     positive regulation of leukocyte cell-cell adhesion GO:1903039 ISO     positive regulation of leukocyte tethering or rolling GO:1903238 ISO     cellular response to amyloid-beta GO:1904646 ISO     vascular associated smooth muscle cell migration GO:1904738 IMP     pericyte cell migration GO:1905351 IMP     positive regulation of vascular endothelial cell proliferation GO:1905564 ISO     neuron projection extension GO:1990138 ISO     clathrin-dependent extracellular exosome endocytosis GO:1990771 ISO     positive regulation of endothelial cell apoptotic process GO:2000353 ISO     positive regulation of T cell migration GO:2000406 ISO Subcellular Localization     plasma membrane GO:0005886 ISO     cell-cell junction GO:0005911 IDA     integrin complex GO:0008305 IBA     external side of plasma membrane GO:0009897 IBA     external side of plasma membrane GO:0009897 IDA     cell surface GO:0009986 ISO     cell surface GO:0009986 TAS     growth cone GO:0030426 ISO     integrin alpha4-beta1 complex GO:0034668 ISO     integrin alpha4-beta7 complex GO:0034669 ISO     neuronal cell body GO:0043025 ISO