Gene description for Ighg1
Gene name immunoglobulin heavy constant gamma 1 (G1m marker)
Gene symbol Ighg1
Other names/aliases IgG1
Igh-4
VH7183
Species Mus musculus
 Database cross references - Ighg1
ExoCarta ExoCarta_16017
Vesiclepedia VP_16017
Entrez Gene 16017
 Ighg1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ighg1
Molecular Function
    antigen binding GO:0003823 IBA
    antigen binding GO:0003823 IDA
    immunoglobulin receptor binding GO:0034987 IBA
    Fc-gamma receptor I complex binding GO:0034988 ISO
Biological Process
    antibody-dependent cellular cytotoxicity GO:0001788 IDA
    positive regulation of type IIa hypersensitivity GO:0001798 IDA
    positive regulation of type I hypersensitivity GO:0001812 IDA
    immunoglobulin production GO:0002377 IMP
    humoral immune response mediated by circulating immunoglobulin GO:0002455 IDA
    phagocytosis, recognition GO:0006910 IDA
    phagocytosis, engulfment GO:0006911 IDA
    complement activation, classical pathway GO:0006958 IBA
    complement activation, classical pathway GO:0006958 IDA
    immunoglobulin mediated immune response GO:0016064 IDA
    antibacterial humoral response GO:0019731 IBA
    antibacterial humoral response GO:0019731 IDA
    B cell differentiation GO:0030183 IGI
    B cell differentiation GO:0030183 IMP
    defense response to bacterium GO:0042742 IDA
    positive regulation of phagocytosis GO:0050766 IDA
    positive regulation of immune response GO:0050778 IDA
Subcellular Localization
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 ISO
    cytoplasm GO:0005737 IDA
    external side of plasma membrane GO:0009897 IDA
    immunoglobulin complex, circulating GO:0042571 IBA
    immunoglobulin complex, circulating GO:0042571 IDA
    IgG immunoglobulin complex GO:0071735 ISO
 Experiment description of studies that identified Ighg1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ighg1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
2 Eed  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Ighg1 is involved
No pathways found





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