Gene description for Igfbp2
Gene name insulin-like growth factor binding protein 2
Gene symbol Igfbp2
Other names/aliases AI255832
IBP-2
Igfbp-2
mIGFBP-2
Species Mus musculus
 Database cross references - Igfbp2
ExoCarta ExoCarta_16008
Vesiclepedia VP_16008
Entrez Gene 16008
UniProt P47877  
 Igfbp2 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Igfbp2
Molecular Function
    protein phosphatase inhibitor activity GO:0004864 IEA
    insulin-like growth factor binding GO:0005520 IPI
    signaling receptor inhibitor activity GO:0030547 IEA
    insulin-like growth factor I binding GO:0031994 IBA
    insulin-like growth factor I binding GO:0031994 ISO
    insulin-like growth factor I binding GO:0031994 ISS
    insulin-like growth factor II binding GO:0031995 IBA
    insulin-like growth factor II binding GO:0031995 ISO
    insulin-like growth factor II binding GO:0031995 ISS
    receptor ligand inhibitor activity GO:0141069 IEA
Biological Process
    osteoblast differentiation GO:0001649 IEA
    female pregnancy GO:0007565 IEA
    response to nutrient GO:0007584 IEA
    response to xenobiotic stimulus GO:0009410 IEA
    response to mechanical stimulus GO:0009612 IEA
    response to estradiol GO:0032355 IEA
    response to retinoic acid GO:0032526 IEA
    cellular response to hormone stimulus GO:0032870 IEA
    positive regulation of activated T cell proliferation GO:0042104 ISO
    positive regulation of activated T cell proliferation GO:0042104 ISS
    regulation of insulin-like growth factor receptor signaling pathway GO:0043567 IBA
    regulation of insulin-like growth factor receptor signaling pathway GO:0043567 ISS
    response to estrogen GO:0043627 IEA
    response to glucocorticoid GO:0051384 IEA
Subcellular Localization
    extracellular region GO:0005576 ISO
    extracellular region GO:0005576 ISS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 ISO
    apical plasma membrane GO:0016324 IEA
    apical plasma membrane GO:0016324 ISO
 Experiment description of studies that identified Igfbp2 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Igfbp2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Itgb1 16412
Co-fractionation Mus musculus
2 Igfbp5  
Co-fractionation Mus musculus
View the network image/svg+xml



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