Gene description for CYP17A1
Gene name cytochrome P450, family 17, subfamily A, polypeptide 1
Gene symbol CYP17A1
Other names/aliases CPT7
Species Homo sapiens
 Database cross references - CYP17A1
ExoCarta ExoCarta_1586
Entrez Gene 1586
HGNC 2593
MIM 609300
UniProt P05093  
 CYP17A1 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for CYP17A1
Molecular Function
    steroid 17-alpha-monooxygenase activity GO:0004508 IMP
    iron ion binding GO:0005506 IEA
    oxygen binding GO:0019825 TAS
    17-alpha-hydroxyprogesterone aldolase activity GO:0047442 IMP
    heme binding GO:0020037 IDA
Biological Process
    ovulation GO:0030728 IEA
    response to insecticide GO:0017085 IEA
    hormone biosynthetic process GO:0042446 IDA
    sterol metabolic process GO:0016125 TAS
    adrenal gland development GO:0030325 IEA
    oxidation-reduction process GO:0055114 IEA
    sex differentiation GO:0007548 TAS
    response to ionizing radiation GO:0010212 IEA
    response to steroid hormone GO:0048545 IEA
    small molecule metabolic process GO:0044281 TAS
    hippocampus development GO:0021766 IEA
    phenol-containing compound metabolic process GO:0018958 IEA
    phthalate metabolic process GO:0018963 IEA
    xenobiotic metabolic process GO:0006805 TAS
    response to drug GO:0042493 IEA
    response to cytokine GO:0034097 IEA
    Leydig cell differentiation GO:0033327 IEA
    steroid biosynthetic process GO:0006694 TAS
    response to retinoic acid GO:0032526 IEA
    dibenzo-p-dioxin metabolic process GO:0018894 IEA
    positive regulation of steroid hormone biosynthetic process GO:0090031 IEA
    cellular response to antibiotic GO:0071236 IEA
    response to methylmercury GO:0051597 IEA
    cellular response to gonadotropin stimulus GO:0071371 IEA
    androgen biosynthetic process GO:0006702 TAS
    response to nutrient levels GO:0031667 IEA
    glucocorticoid biosynthetic process GO:0006704 TAS
    cellular response to lipopolysaccharide GO:0071222 IEA
    biphenyl metabolic process GO:0018879 IEA
    response to cAMP GO:0051591 IEA
    steroid metabolic process GO:0008202 TAS
    progesterone metabolic process GO:0042448 IDA
    response to acetate GO:0010034 IEA
    response to herbicide GO:0009635 IEA
    response to fungicide GO:0060992 IEA
Subcellular Localization
    neuronal cell body GO:0043025 IEA
    endoplasmic reticulum membrane GO:0005789 TAS
    mitochondrion GO:0005739 IEA
    axon GO:0030424 IEA
    endoplasmic reticulum GO:0005783 NAS
 Experiment description of studies that identified CYP17A1 in exosomes
Experiment ID 275
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for CYP17A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CYB5A 1528
Invitro Homo sapiens
2 POR 5447
Invivo Homo sapiens
View the network image/svg+xml

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