Gene description for Hpx
Gene name hemopexin
Gene symbol Hpx
Other names/aliases Hpxn
hx
Species Mus musculus
 Database cross references - Hpx
ExoCarta ExoCarta_15458
Vesiclepedia VP_15458
Entrez Gene 15458
UniProt Q91X72  
 Hpx identified in sEVs derived from the following tissue/cell type
Faeces 33431899    
Faeces 33431899    
 Gene ontology annotations for Hpx
Molecular Function
    heme transmembrane transporter activity GO:0015232 IEA
    heme binding GO:0020037 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    positive regulation of immunoglobulin production GO:0002639 IMP
    positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 IMP
    intracellular iron ion homeostasis GO:0006879 IEA
    tyrosine phosphorylation of STAT protein GO:0007260 IMP
    heme transport GO:0015886 IEA
    hemoglobin metabolic process GO:0020027 IMP
    heme metabolic process GO:0042168 IBA
    heme metabolic process GO:0042168 IMP
    positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 IMP
    regulation of protein metabolic process GO:0051246 IMP
    positive regulation of response to type II interferon GO:0060332 IMP
    type II interferon-mediated signaling pathway GO:0060333 IMP
    positive regulation of type II interferon-mediated signaling pathway GO:0060335 IMP
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Hpx in sEVs
1
Experiment ID 303
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
2
Experiment ID 304
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
 Protein-protein interactions for Hpx
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kcnma1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml



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