Gene description for Hpd
Gene name 4-hydroxyphenylpyruvic acid dioxygenase
Gene symbol Hpd
Other names/aliases Fla
Flp
Hppd
Laf
Species Mus musculus
 Database cross references - Hpd
ExoCarta ExoCarta_15445
Vesiclepedia VP_15445
Entrez Gene 15445
UniProt P49429  
 Hpd identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Hpd
Molecular Function
    4-hydroxyphenylpyruvate dioxygenase activity GO:0003868 IBA
    4-hydroxyphenylpyruvate dioxygenase activity GO:0003868 ISO
    4-hydroxyphenylpyruvate dioxygenase activity GO:0003868 ISS
    iron ion binding GO:0005506 ISO
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 ISO
    protein homodimerization activity GO:0042803 ISS
    metal ion binding GO:0046872 IEA
Biological Process
    L-phenylalanine catabolic process GO:0006559 IEA
    tyrosine catabolic process GO:0006572 IBA
    tyrosine catabolic process GO:0006572 ISO
    tyrosine catabolic process GO:0006572 ISO
    tyrosine catabolic process GO:0006572 ISS
Subcellular Localization
    Golgi membrane GO:0000139 IBA
    Golgi membrane GO:0000139 IEA
    Golgi membrane GO:0000139 ISO
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 IEA
    endoplasmic reticulum membrane GO:0005789 ISO
    Golgi apparatus GO:0005794 ISO
 Experiment description of studies that identified Hpd in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Hpd
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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