Gene description for Hpca
Gene name hippocalcin
Gene symbol Hpca
Other names/aliases -
Species Mus musculus
 Database cross references - Hpca
ExoCarta ExoCarta_15444
Vesiclepedia VP_15444
Entrez Gene 15444
UniProt P84075  
 Hpca identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Hpca
Molecular Function
    actin binding GO:0003779 ISO
    actin binding GO:0003779 ISS
    calcium ion binding GO:0005509 IBA
    calcium ion binding GO:0005509 ISO
    calcium ion binding GO:0005509 ISS
    protein binding GO:0005515 IPI
    kinase binding GO:0019900 IEA
    kinase binding GO:0019900 ISO
    identical protein binding GO:0042802 ISO
    identical protein binding GO:0042802 ISS
Biological Process
    regulation of signal transduction GO:0009966 IBA
    calcium-mediated signaling GO:0019722 IEA
    inner ear development GO:0048839 IDA
    retina development in camera-type eye GO:0060041 IEA
    cellular response to electrical stimulus GO:0071257 IEA
    cellular response to calcium ion GO:0071277 ISO
    cellular response to calcium ion GO:0071277 ISS
    positive regulation of protein targeting to membrane GO:0090314 IEA
    positive regulation of protein targeting to membrane GO:0090314 ISO
    regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 IEA
    regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 ISO
    regulation of voltage-gated calcium channel activity GO:1901385 ISO
    regulation of voltage-gated calcium channel activity GO:1901385 ISS
    response to ketamine GO:1901986 IEA
    response to Aroclor 1254 GO:1904010 IEA
    cellular response to L-glutamate GO:1905232 IEA
    cellular response to L-glutamate GO:1905232 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    membrane GO:0016020 ISO
    membrane GO:0016020 ISS
    axon GO:0030424 IEA
    axon GO:0030424 ISO
    dendrite membrane GO:0032590 IEA
    dendrite membrane GO:0032590 ISO
    neuronal cell body membrane GO:0032809 IEA
    neuronal cell body membrane GO:0032809 ISO
    dendrite cytoplasm GO:0032839 IEA
    dendrite cytoplasm GO:0032839 ISO
    perikaryon GO:0043204 IEA
    perikaryon GO:0043204 ISO
    dendritic spine head GO:0044327 IEA
    dendritic spine head GO:0044327 ISO
    postsynapse GO:0098794 ISO
    glutamatergic synapse GO:0098978 IEA
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Hpca in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Hpca
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kctd13  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Hpca is involved
No pathways found





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