Gene description for Hp1bp3
Gene name heterochromatin protein 1, binding protein 3
Gene symbol Hp1bp3
Other names/aliases Hp1bp74
Species Mus musculus
 Database cross references - Hp1bp3
ExoCarta ExoCarta_15441
Vesiclepedia VP_15441
Entrez Gene 15441
UniProt Q3TEA8  
 Hp1bp3 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Hp1bp3
Molecular Function
    DNA binding GO:0003677 IBA
    DNA binding GO:0003677 ISO
    DNA binding GO:0003677 ISS
    structural constituent of chromatin GO:0030527 IEA
    nucleosome binding GO:0031491 IBA
    nucleosome binding GO:0031491 ISO
    nucleosome binding GO:0031491 ISS
Biological Process
    nucleosome assembly GO:0006334 IEA
    regulation of DNA-templated transcription GO:0006355 ISO
    regulation of DNA-templated transcription GO:0006355 ISS
    regulation of cell population proliferation GO:0042127 ISO
    regulation of cell population proliferation GO:0042127 ISS
    heterochromatin organization GO:0070828 IBA
    heterochromatin organization GO:0070828 ISO
    heterochromatin organization GO:0070828 ISS
    cellular response to hypoxia GO:0071456 ISO
    cellular response to hypoxia GO:0071456 ISS
    regulation of nucleus size GO:0097298 ISO
    regulation of nucleus size GO:0097298 ISS
Subcellular Localization
    nucleosome GO:0000786 IEA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    chromosome GO:0005694 IBA
    chromosome GO:0005694 ISO
    chromosome GO:0005694 ISS
    nuclear speck GO:0016607 ISO
 Experiment description of studies that identified Hp1bp3 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Hp1bp3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rnf2  
Affinity Capture-MS Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
3 Atxn1  
Affinity Capture-MS Mus musculus
4 Cebpa  
Affinity Capture-MS Mus musculus
5 Cul3  
Affinity Capture-MS Mus musculus
6 Zbtb16  
Affinity Capture-MS Mus musculus
7 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Hp1bp3 is involved
No pathways found





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