Gene description for Hipk3
Gene name homeodomain interacting protein kinase 3
Gene symbol Hipk3
Other names/aliases DYRK6
FIST3
PKY
mir-1902
Species Mus musculus
 Database cross references - Hipk3
ExoCarta ExoCarta_15259
Vesiclepedia VP_15259
Entrez Gene 15259
UniProt Q9ERH7  
 Hipk3 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Hipk3
Molecular Function
    DNA binding GO:0003677 ISS
    transcription corepressor activity GO:0003714 ISS
    protein kinase activity GO:0004672 ISO
    protein kinase activity GO:0004672 ISS
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein tyrosine kinase activity GO:0004713 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 ISO
    protein phosphorylation GO:0006468 ISS
    apoptotic process GO:0006915 IEA
    mRNA transcription GO:0009299 ISO
    peptidyl-serine phosphorylation GO:0018105 IDA
    peptidyl-threonine phosphorylation GO:0018107 IDA
    negative regulation of apoptotic process GO:0043066 ISO
    positive regulation of DNA binding GO:0043388 ISS
    negative regulation of JUN kinase activity GO:0043508 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 ISO
    nuclear body GO:0016604 ISO
    PML body GO:0016605 IBA
    PML body GO:0016605 IDA
 Experiment description of studies that identified Hipk3 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Hipk3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GLIS3  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which Hipk3 is involved
No pathways found





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