Gene description for Hbb-b2
Gene name hemoglobin, beta adult minor chain
Gene symbol Hbb-b2
Other names/aliases AI036344
Hbb2
Hbbt2
beta2
Species Mus musculus
 Database cross references - Hbb-b2
ExoCarta ExoCarta_15130
Vesiclepedia VP_15130
Entrez Gene 15130
UniProt P02089  
 Hbb-b2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Hbb-b2
Molecular Function
    peroxidase activity GO:0004601 IBA
    peroxidase activity GO:0004601 ISO
    oxygen carrier activity GO:0005344 IBA
    oxygen carrier activity GO:0005344 IEA
    protein binding GO:0005515 IPI
    oxygen binding GO:0019825 IMP
    oxygen binding GO:0019825 ISO
    oxygen binding GO:0019825 ISO
    heme binding GO:0020037 IBA
    heme binding GO:0020037 IEA
    hemoglobin binding GO:0030492 ISO
    haptoglobin binding GO:0031720 IBA
    haptoglobin binding GO:0031720 ISO
    hemoglobin alpha binding GO:0031721 IBA
    hemoglobin alpha binding GO:0031721 ISO
    hemoglobin beta binding GO:0031722 ISO
    protein-containing complex binding GO:0044877 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    carbon dioxide transport GO:0015670 NAS
    oxygen transport GO:0015671 ISO
    myeloid cell differentiation GO:0030099 IMP
    nitric oxide transport GO:0030185 ISO
    hydrogen peroxide catabolic process GO:0042744 IBA
    positive regulation of myeloid cell differentiation GO:0045639 IMP
    regulation of erythrocyte differentiation GO:0045646 IMP
    erythrocyte development GO:0048821 IGI
Subcellular Localization
    extracellular space GO:0005615 ISO
    hemoglobin complex GO:0005833 IBA
    hemoglobin complex GO:0005833 IMP
    hemoglobin complex GO:0005833 ISO
    hemoglobin complex GO:0005833 ISS
    haptoglobin-hemoglobin complex GO:0031838 IBA
    haptoglobin-hemoglobin complex GO:0031838 ISO
 Experiment description of studies that identified Hbb-b2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Hbb-b2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
2 Kcnma1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Hbb-b2 is involved
No pathways found





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