Gene description for H2-L
Gene name histocompatibility 2, D region locus L
Gene symbol H2-L
Other names/aliases H-2L
Species Mus musculus
 Database cross references - H2-L
ExoCarta ExoCarta_14980
Vesiclepedia VP_14980
Entrez Gene 14980
 H2-L identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for H2-L
Molecular Function
    signaling receptor binding GO:0005102 IBA
    signaling receptor binding GO:0005102 ISO
    beta-2-microglobulin binding GO:0030881 ISO
    MHC class I protein binding GO:0042288 ISO
    peptide antigen binding GO:0042605 IBA
    peptide antigen binding GO:0042605 ISO
    T cell receptor binding GO:0042608 ISO
    natural killer cell lectin-like receptor binding GO:0046703 ISO
    TAP binding GO:0046977 ISO
    protein-folding chaperone binding GO:0051087 ISO
Biological Process
    positive regulation of T cell mediated cytotoxicity GO:0001916 IBA
    antigen processing and presentation of peptide antigen via MHC class I GO:0002474 IEA
    antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 IBA
    antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent GO:0002486 IBA
    defense response GO:0006952 TAS
    immune response GO:0006955 IBA
    immune response GO:0006955 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
    endoplasmic reticulum GO:0005783 ISO
    Golgi apparatus GO:0005794 ISO
    plasma membrane GO:0005886 ISO
    external side of plasma membrane GO:0009897 IBA
    cell surface GO:0009986 ISO
    phagocytic vesicle membrane GO:0030670 TAS
    MHC class Ib protein complex GO:0032398 ISO
    MHC class I protein complex GO:0042612 IEA
    MHC class I protein complex GO:0042612 ISO
    lumenal side of endoplasmic reticulum membrane GO:0098553 TAS
 Experiment description of studies that identified H2-L in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for H2-L
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which H2-L is involved
No pathways found





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