Gene description for H2-Ab1
Gene name histocompatibility 2, class II antigen A, beta 1
Gene symbol H2-Ab1
Other names/aliases AI845868
Abeta
H-2Ab
H2-Ab
I-Abeta
IAb
Ia-2
Ia2
Rmcs1
Species Mus musculus
 Database cross references - H2-Ab1
ExoCarta ExoCarta_14961
Vesiclepedia VP_14961
Entrez Gene 14961
UniProt P14483  
 H2-Ab1 identified in sEVs derived from the following tissue/cell type
Dendritic cells 10545503    
 Gene ontology annotations for H2-Ab1
Molecular Function
    protein binding GO:0005515 IPI
    MHC class II protein complex binding GO:0023026 IBA
    peptide antigen binding GO:0042605 IBA
    peptide antigen binding GO:0042605 IDA
    protein-containing complex binding GO:0044877 ISO
Biological Process
    peptide antigen assembly with MHC class II protein complex GO:0002503 IBA
    immune response GO:0006955 IMP
    antigen processing and presentation GO:0019882 IDA
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IBA
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IDA
    antigen processing and presentation of peptide antigen GO:0048002 IDA
    positive regulation of immune response GO:0050778 IBA
    positive regulation of T cell activation GO:0050870 IBA
Subcellular Localization
    intracellular anatomical structure GO:0005622 IDA
    lysosomal membrane GO:0005765 IBA
    early endosome GO:0005769 IDA
    multivesicular body GO:0005771 IDA
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 IDA
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 ISO
    membrane GO:0016020 IDA
    late endosome membrane GO:0031902 IBA
    MHC class II protein complex GO:0042613 IBA
    MHC class II protein complex GO:0042613 IDA
 Experiment description of studies that identified H2-Ab1 in sEVs
1
Experiment ID 3
MISEV standards
✔
IEM
Biophysical techniques
✔
HSP84|HSC73|MHCII|CD9|mac-1
Enriched markers
✔
CANX|HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
Western blotting
PubMed ID 10545503    
Organism Mus musculus
Experiment description Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73.
Authors "Thery C, Regnault A, Garin J, Wolfers J, Zitvogel L, Ricciardi-Castagnoli P, Raposo G, Amigorena S."
Journal name JCB
Publication year 1999
Sample Dendritic cells
Sample name D1
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for H2-Ab1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which H2-Ab1 is involved
No pathways found





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