Gene description for Gys1
Gene name glycogen synthase 1, muscle
Gene symbol Gys1
Other names/aliases Gys3
MGS
Species Mus musculus
 Database cross references - Gys1
ExoCarta ExoCarta_14936
Vesiclepedia VP_14936
Entrez Gene 14936
UniProt Q9Z1E4  
 Gys1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Gys1
Molecular Function
    alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity GO:0004373 IBA
    alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity GO:0004373 IDA
    alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity GO:0004373 IMP
    alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity GO:0004373 ISO
    protein binding GO:0005515 IPI
    D-glucose binding GO:0005536 IEA
    D-glucose binding GO:0005536 ISO
    glycogen synthase activity, transferring glucose-1-phosphate GO:0061547 IDA
    glycogen synthase activity, transferring glucose-1-phosphate GO:0061547 ISO
Biological Process
    glycogen metabolic process GO:0005977 ISO
    glycogen biosynthetic process GO:0005978 IBA
    glycogen biosynthetic process GO:0005978 IDA
    glycogen biosynthetic process GO:0005978 IEA
    glycogen biosynthetic process GO:0005978 IMP
    glycogen biosynthetic process GO:0005978 IMP
    glycogen biosynthetic process GO:0005978 ISO
    heart development GO:0007507 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    inclusion body GO:0016234 IDA
 Experiment description of studies that identified Gys1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Gys1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ABCG1  
Affinity Capture-MS Homo sapiens
2 Pik3r4  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Gys1 is involved
PathwayEvidenceSource
Glycogen metabolism IEA Reactome
Glycogen synthesis IEA Reactome
Metabolism IEA Reactome
Metabolism of carbohydrates IEA Reactome





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