Gene description for Lilrb4
Gene name leukocyte immunoglobulin-like receptor, subfamily B, member 4
Gene symbol Lilrb4
Other names/aliases CD85K
Gp49b
HM18
ILT3
LIR-5
gp49
Species Mus musculus
 Database cross references - Lilrb4
ExoCarta ExoCarta_14728
Vesiclepedia VP_14728
Entrez Gene 14728
UniProt Q64281  
 Lilrb4 identified in sEVs derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Lilrb4
Molecular Function
    fibronectin binding GO:0001968 IDA
    fibronectin binding GO:0001968 ISO
    integrin binding GO:0005178 IDA
    phosphatase binding GO:0019902 IPI
    protein phosphatase binding GO:0019903 IPI
    protein phosphatase binding GO:0019903 ISO
    transmembrane receptor protein tyrosine kinase inhibitor activity GO:0030293 ISO
    signaling receptor inhibitor activity GO:0030547 ISO
    apolipoprotein binding GO:0034185 ISO
Biological Process
    neutrophil homeostasis GO:0001780 IMP
    cytokine production GO:0001816 IMP
    adaptive immune response GO:0002250 IEA
    inflammatory response to antigenic stimulus GO:0002437 IMP
    tolerance induction GO:0002507 ISO
    negative regulation of immunoglobulin production GO:0002638 IMP
    positive regulation of T cell anergy GO:0002669 ISO
    negative regulation of T cell cytokine production GO:0002725 ISO
    immune response-regulating signaling pathway GO:0002764 IBA
    Fc receptor mediated inhibitory signaling pathway GO:0002774 ISO
    inflammatory response GO:0006954 IMP
    blood coagulation GO:0007596 IMP
    response to wounding GO:0009611 IMP
    response to nematode GO:0009624 IMP
    receptor internalization GO:0031623 ISO
    response to lipopolysaccharide GO:0032496 IMP
    chemokine production GO:0032602 IMP
    negative regulation of chemokine production GO:0032682 ISO
    negative regulation of type II interferon production GO:0032689 ISO
    negative regulation of interleukin-1 beta production GO:0032691 ISO
    negative regulation of interleukin-10 production GO:0032693 ISO
    negative regulation of interleukin-2 production GO:0032703 ISO
    negative regulation of interleukin-5 production GO:0032714 ISO
    negative regulation of interleukin-6 production GO:0032715 ISO
    negative regulation of tumor necrosis factor production GO:0032720 ISO
    negative regulation of natural killer cell activation GO:0032815 IDA
    negative regulation of mast cell activation GO:0033004 IMP
    negative regulation of mast cell activation involved in immune response GO:0033007 IDA
    negative regulation of mast cell activation involved in immune response GO:0033007 IMP
    negative regulation of mast cell activation involved in immune response GO:0033007 IPI
    CD4-positive, alpha-beta T cell proliferation GO:0035739 IMP
    CD8-positive, alpha-beta T cell proliferation GO:0035740 IMP
    type 2 immune response GO:0042092 IMP
    negative regulation of T cell proliferation GO:0042130 ISO
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 ISO
    positive regulation of CD8-positive, alpha-beta T cell differentiation GO:0043378 ISO
    negative regulation of MAPK cascade GO:0043409 ISO
    negative regulation of cytotoxic T cell differentiation GO:0045584 ISO
    positive regulation of regulatory T cell differentiation GO:0045591 ISO
    negative regulation of osteoclast differentiation GO:0045671 ISO
    negative regulation of activated T cell proliferation GO:0046007 ISO
    negative regulation of T cell receptor signaling pathway GO:0050860 ISO
    response to other organism GO:0051707 IMP
    negative regulation of protein tyrosine kinase activity GO:0061099 ISO
    cellular response to lipopolysaccharide GO:0071222 IMP
    negative regulation of IP-10 production GO:0071659 ISO
    negative regulation of monocyte activation GO:0150102 IDA
    negative regulation of monocyte activation GO:0150102 ISO
    negative regulation of cytokine production involved in inflammatory response GO:1900016 ISO
    negative regulation of plasma cell differentiation GO:1900099 IMP
    negative regulation of protein localization to nucleus GO:1900181 ISO
    negative regulation of miRNA transcription GO:1902894 ISO
    negative regulation of signaling receptor activity GO:2000272 ISO
    negative regulation of T cell costimulation GO:2000524 ISO
Subcellular Localization
    plasma membrane GO:0005886 IBA
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
 Experiment description of studies that identified Lilrb4 in sEVs
1
Experiment ID 214
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Lilrb4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Lilrb4 is involved
No pathways found





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