Gene description for Gh
Gene name growth hormone
Gene symbol Gh
Other names/aliases Gh1
Species Mus musculus
 Database cross references - Gh
ExoCarta ExoCarta_14599
Vesiclepedia VP_14599
Entrez Gene 14599
UniProt P06880  
 Gh identified in sEVs derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Gh
Molecular Function
    cytokine activity GO:0005125 ISO
    growth hormone receptor binding GO:0005131 IBA
    growth hormone receptor binding GO:0005131 IPI
    growth hormone receptor binding GO:0005131 ISO
    prolactin receptor binding GO:0005148 ISO
    hormone activity GO:0005179 IBA
    hormone activity GO:0005179 IEA
    hormone activity GO:0005179 ISO
    growth factor activity GO:0008083 IBA
    growth factor activity GO:0008083 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    signal transduction GO:0007165 IEA
    neuroblast proliferation GO:0007405 IEA
    neuroblast proliferation GO:0007405 ISO
    female pregnancy GO:0007565 IEA
    response to light stimulus GO:0009416 IEA
    response to light stimulus GO:0009416 ISO
    positive regulation of D-glucose transmembrane transport GO:0010828 ISO
    response to nutrient levels GO:0031667 IBA
    response to food GO:0032094 IDA
    regulation of response to nutrient levels GO:0032107 IEA
    regulation of response to nutrient levels GO:0032107 ISO
    response to estradiol GO:0032355 IEA
    cellular response to insulin stimulus GO:0032869 IDA
    regulation of intracellular steroid hormone receptor signaling pathway GO:0033143 ISO
    response to cytokine GO:0034097 IEA
    positive regulation of multicellular organism growth GO:0040018 IGI
    positive regulation of growth GO:0045927 ISO
    positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 IBA
    lung alveolus development GO:0048286 IEA
    lung alveolus development GO:0048286 ISO
    animal organ development GO:0048513 IBA
    positive regulation of neurogenesis GO:0050769 IEA
    positive regulation of neurogenesis GO:0050769 ISO
    growth hormone receptor signaling pathway GO:0060396 IBA
    cellular response to alkaline pH GO:0071469 IEA
    positive regulation of steroid hormone biosynthetic process GO:0090031 IEA
    positive regulation of steroid hormone biosynthetic process GO:0090031 ISO
    cellular response to thyroid hormone stimulus GO:0097067 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 ISO
    nucleus GO:0005634 IDA
    endoplasmic reticulum GO:0005783 ISO
    trans-Golgi network GO:0005802 IDA
    plasma membrane GO:0005886 IDA
    secretory granule GO:0030141 IDA
    secretory granule GO:0030141 ISO
    vesicle GO:0031982 ISO
    collagen-containing extracellular matrix GO:0062023 IEA
    collagen-containing extracellular matrix GO:0062023 ISO
    growth hormone receptor complex GO:0070195 ISO
 Experiment description of studies that identified Gh in sEVs
1
Experiment ID 188
MISEV standards
EM
Biophysical techniques
GAPDH|UCHL1|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Gh
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Socs2  
Affinity Capture-Western Mus musculus
2 Prl2c2  
Reconstituted Complex Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here