Gene description for Ftl2
Gene name ferritin light chain 2
Gene symbol Ftl2
Other names/aliases Ftl
Ftl-2
Species Mus musculus
 Database cross references - Ftl2
ExoCarta ExoCarta_14337
Vesiclepedia VP_14337
Entrez Gene 14337
 Ftl2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ftl2
Molecular Function
    iron ion binding GO:0005506 ISO
    iron ion binding GO:0005506 ISS
    ferrous iron binding GO:0008198 IBA
    ferric iron binding GO:0008199 IBA
    ferric iron binding GO:0008199 IEA
    identical protein binding GO:0042802 ISO
Biological Process
    iron ion transport GO:0006826 IEA
    intracellular iron ion homeostasis GO:0006879 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    autophagosome GO:0005776 IEA
    cytoplasmic vesicle GO:0031410 IEA
    autolysosome GO:0044754 IEA
    ferritin complex GO:0070288 ISO
    ferritin complex GO:0070288 ISS
 Experiment description of studies that identified Ftl2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ftl2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ftl2 is involved
No pathways found





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