Gene description for Fcgr1
Gene name Fc receptor, IgG, high affinity I
Gene symbol Fcgr1
Other names/aliases AI323638
AV092959
CD64
FcgammaRI
IGGHAFC
Species Mus musculus
 Database cross references - Fcgr1
ExoCarta ExoCarta_14129
Vesiclepedia VP_14129
Entrez Gene 14129
UniProt P26151  
 Fcgr1 identified in sEVs derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Fcgr1
Molecular Function
    IgG receptor activity GO:0019770 IBA
    IgG receptor activity GO:0019770 IMP
    high-affinity IgG receptor activity GO:0019771 IEA
    high-affinity IgG receptor activity GO:0019771 ISO
    IgG binding GO:0019864 IBA
    IgG binding GO:0019864 IDA
    IgG binding GO:0019864 IMP
    leukotriene receptor binding GO:0031774 ISO
Biological Process
    antibody-dependent cellular cytotoxicity GO:0001788 IBA
    antibody-dependent cellular cytotoxicity GO:0001788 IMP
    positive regulation of type IIa hypersensitivity GO:0001798 IMP
    positive regulation of type III hypersensitivity GO:0001805 IMP
    receptor-mediated endocytosis GO:0006898 IMP
    phagocytosis, recognition GO:0006910 IMP
    phagocytosis, engulfment GO:0006911 IMP
    cell surface receptor signaling pathway GO:0007166 IBA
    cell surface receptor signaling pathway GO:0007166 IMP
    response to bacterium GO:0009617 IMP
    antigen processing and presentation of exogenous antigen GO:0019884 IMP
    positive regulation of tumor necrosis factor production GO:0032760 IBA
    Fc-gamma receptor signaling pathway GO:0038094 IEA
    antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590 IMP
    defense response to bacterium GO:0042742 IMP
    innate immune response GO:0045087 IEA
    positive regulation of phagocytosis GO:0050766 IBA
    positive regulation of phagocytosis GO:0050766 IMP
    regulation of immune response GO:0050776 IMP
    positive regulation of phagocytosis, engulfment GO:0060100 ISO
Subcellular Localization
    plasma membrane GO:0005886 ISO
    external side of plasma membrane GO:0009897 IBA
    external side of plasma membrane GO:0009897 IDA
 Experiment description of studies that identified Fcgr1 in sEVs
1
Experiment ID 214
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors "Hassani K, Olivier M."
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Fcgr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Zbtb7b  
Affinity Capture-MS Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
3 Tmem173  
Proximity Label-MS Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here