Gene description for Fbp2
Gene name fructose bisphosphatase 2
Gene symbol Fbp2
Other names/aliases Fbp-1
Fbp1
Rae-30
Species Mus musculus
 Database cross references - Fbp2
ExoCarta ExoCarta_14120
Vesiclepedia VP_14120
Entrez Gene 14120
UniProt P70695  
 Fbp2 identified in sEVs derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Fbp2
Molecular Function
    fructose 1,6-bisphosphate 1-phosphatase activity GO:0042132 IBA
    fructose 1,6-bisphosphate 1-phosphatase activity GO:0042132 IEA
    fructose 1,6-bisphosphate 1-phosphatase activity GO:0042132 ISO
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    metal ion binding GO:0046872 IEA
Biological Process
    fructose metabolic process GO:0006000 IBA
    fructose 6-phosphate metabolic process GO:0006002 IBA
    gluconeogenesis GO:0006094 IBA
    gluconeogenesis GO:0006094 IEA
    gluconeogenesis GO:0006094 ISO
    fructose 1,6-bisphosphate metabolic process GO:0030388 IBA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    Z disc GO:0030018 IEA
    anchoring junction GO:0070161 IEA
 Experiment description of studies that identified Fbp2 in sEVs
1
Experiment ID 188
MISEV standards
EM
Biophysical techniques
GAPDH|UCHL1|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Fbp2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Stk11  
Co-fractionation Mus musculus
2 Mtor  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Fbp2 is involved
PathwayEvidenceSource
Gluconeogenesis IEA Reactome
Glucose metabolism IEA Reactome
Metabolism IEA Reactome
Metabolism of carbohydrates IEA Reactome





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