Gene description for Fas
Gene name Fas (TNF receptor superfamily member 6)
Gene symbol Fas
Other names/aliases AI196731
Species Mus musculus
 Database cross references - Fas
ExoCarta ExoCarta_14102
Entrez Gene 14102
UniProt P25446  
 Fas identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Fas
Molecular Function
    kinase binding GO:0019900 ISO
    protein binding GO:0005515 IPI
    protease binding GO:0002020 ISO
    tumor necrosis factor-activated receptor activity GO:0005031 ISO
    identical protein binding GO:0042802 ISO
    protein complex binding GO:0032403 ISO
    transmembrane signaling receptor activity GO:0004888 IEA
Biological Process
    transformed cell apoptotic process GO:0006927 IDA
    inflammatory cell apoptotic process GO:0006925 IMP
    apoptotic signaling pathway GO:0097190 ISO
    tumor necrosis factor-mediated signaling pathway GO:0033209 ISO
    positive regulation of cell death GO:0010942 ISO
    protein homooligomerization GO:0051260 IDA
    gene expression GO:0010467 IMP
    activation-induced cell death of T cells GO:0006924 IMP
    extrinsic apoptotic signaling pathway GO:0097191 ISO
    response to glucocorticoid GO:0051384 IMP
    positive regulation of apoptotic process GO:0043065 ISO
    positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 IMP
    regulation of lymphocyte differentiation GO:0045619 IMP
    negative regulation of B cell activation GO:0050869 IMP
    negative regulation of apoptotic process GO:0043066 IDA
    positive regulation of release of cytochrome c from mitochondria GO:0090200 IC
    regulation of myeloid cell differentiation GO:0045637 IMP
    immunoglobulin production GO:0002377 IMP
    apoptotic process GO:0006915 ISO
    positive regulation of protein homooligomerization GO:0032464 IDA
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 ISO
    negative thymic T cell selection GO:0045060 IMP
    signal transduction GO:0007165 IEA
    hepatocyte apoptotic process GO:0097284 IGI
    cellular response to hyperoxia GO:0071455 ISO
    spleen development GO:0048536 IMP
    extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IMP
    regulation of apoptotic process GO:0042981 ISO
    regulation of gene expression GO:0010468 ISO
    T cell homeostasis GO:0043029 IMP
    cellular response to lithium ion GO:0071285 IMP
    response to toxic substance GO:0009636 IMP
    necroptotic signaling pathway GO:0097527 ISO
    B cell mediated immunity GO:0019724 IMP
    immune response GO:0006955 IEA
    neuron apoptotic process GO:0051402 IMP
    renal system process GO:0003014 IMP
    regulation of cell proliferation GO:0042127 ISO
    dendrite regeneration GO:0031104 ISO
    extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 IMP
    motor neuron apoptotic process GO:0097049 IMP
Subcellular Localization
    neuron projection GO:0043005 ISO
    apical plasma membrane GO:0016324 ISO
    membrane raft GO:0045121 ISO
    CD95 death-inducing signaling complex GO:0031265 ISO
    external side of plasma membrane GO:0009897 IDA
    nucleus GO:0005634 ISO
    extracellular space GO:0005615 ISO
    extracellular region GO:0005576 IDA
    cytoplasm GO:0005737 ISO
    integral component of membrane GO:0016021 IEA
    neuronal cell body GO:0043025 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    secretory granule GO:0030141 ISO
    death-inducing signaling complex GO:0031264 ISO
    sarcolemma GO:0042383 ISO
    apical dendrite GO:0097440 ISO
    plasma membrane GO:0005886 ISO
    extracellular exosome GO:0070062 ISO
    membrane GO:0016020 IEA
    cell surface GO:0009986 ISO
 Experiment description of studies that identified Fas in exosomes
Experiment ID 15
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for Fas
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ube2i  
Two-hybrid Mus musculus
2 DAXX  
Two-hybrid Homo sapiens
View the network image/svg+xml

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