Gene description for Fscn1
Gene name fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)
Gene symbol Fscn1
Other names/aliases AI663989
Fan1
fascin-1
Species Mus musculus
 Database cross references - Fscn1
ExoCarta ExoCarta_14086
Vesiclepedia VP_14086
Entrez Gene 14086
UniProt Q61553  
 Fscn1 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Fscn1
Molecular Function
    actin binding GO:0003779 ISO
    protein binding GO:0005515 IPI
    protein-macromolecule adaptor activity GO:0030674 IEA
    actin filament binding GO:0051015 IBA
    actin filament binding GO:0051015 IDA
    actin filament binding GO:0051015 IMP
    actin filament binding GO:0051015 ISO
Biological Process
    cell-cell junction assembly GO:0007043 ISO
    cell-cell junction assembly GO:0007043 ISS
    establishment or maintenance of cell polarity GO:0007163 IBA
    positive regulation of lamellipodium assembly GO:0010592 ISO
    positive regulation of lamellipodium assembly GO:0010592 ISS
    cell migration GO:0016477 IBA
    cell migration GO:0016477 IMP
    cell migration GO:0016477 ISO
    microspike assembly GO:0030035 ISO
    microspike assembly GO:0030035 ISS
    actin cytoskeleton organization GO:0030036 ISO
    parallel actin filament bundle assembly GO:0030046 IEA
    parallel actin filament bundle assembly GO:0030046 ISO
    regulation of microvillus assembly GO:0032534 ISO
    regulation of microvillus assembly GO:0032534 ISS
    regulation of actin cytoskeleton organization GO:0032956 ISO
    regulation of actin cytoskeleton organization GO:0032956 ISS
    establishment of apical/basal cell polarity GO:0035089 ISO
    establishment of apical/basal cell polarity GO:0035089 ISS
    cell motility GO:0048870 ISO
    cell motility GO:0048870 ISS
    actin filament bundle assembly GO:0051017 IBA
    actin filament bundle assembly GO:0051017 IDA
    actin filament bundle assembly GO:0051017 ISO
    positive regulation of filopodium assembly GO:0051491 IMP
    positive regulation of filopodium assembly GO:0051491 ISO
    positive regulation of filopodium assembly GO:0051491 ISS
    positive regulation of podosome assembly GO:0071803 ISO
    positive regulation of podosome assembly GO:0071803 ISS
    positive regulation of extracellular matrix disassembly GO:0090091 ISO
    positive regulation of extracellular matrix disassembly GO:0090091 ISS
Subcellular Localization
    stress fiber GO:0001725 ISO
    stress fiber GO:0001725 ISS
    ruffle GO:0001726 IBA
    ruffle GO:0001726 ISO
    ruffle GO:0001726 ISS
    podosome GO:0002102 ISO
    podosome GO:0002102 ISS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    cytoskeleton GO:0005856 ISO
    cytoskeleton GO:0005856 ISS
    microvillus GO:0005902 IBA
    microvillus GO:0005902 ISO
    microvillus GO:0005902 ISS
    cell-cell junction GO:0005911 ISO
    cell-cell junction GO:0005911 ISS
    cell cortex GO:0005938 IEA
    actin cytoskeleton GO:0015629 IBA
    actin cytoskeleton GO:0015629 ISO
    actin cytoskeleton GO:0015629 ISS
    lamellipodium GO:0030027 IBA
    lamellipodium GO:0030027 IDA
    lamellipodium GO:0030027 ISO
    filopodium GO:0030175 IBA
    filopodium GO:0030175 IDA
    filopodium GO:0030175 ISO
    dendrite GO:0030425 ISO
    growth cone GO:0030426 IBA
    growth cone GO:0030426 IDA
    growth cone GO:0030426 ISO
    cell projection membrane GO:0031253 IBA
    cell projection membrane GO:0031253 ISO
    cell projection membrane GO:0031253 ISS
    myelin sheath GO:0043209 HDA
    microspike GO:0044393 ISO
    microspike GO:0044393 ISS
 Experiment description of studies that identified Fscn1 in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Fscn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mapt  
Affinity Capture-MS Mus musculus
2 Tia1  
Affinity Capture-MS Mus musculus
3 Kctd13  
Affinity Capture-MS Mus musculus
4 MAPT  
Reconstituted Complex Homo sapiens
5 Dlg4  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Fscn1 is involved
No pathways found





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