Gene description for F10
Gene name coagulation factor X
Gene symbol F10
Other names/aliases Cf10
fX
Species Mus musculus
 Database cross references - F10
ExoCarta ExoCarta_14058
Vesiclepedia VP_14058
Entrez Gene 14058
UniProt O88947  
 F10 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for F10
Molecular Function
    serine-type endopeptidase activity GO:0004252 IBA
    serine-type endopeptidase activity GO:0004252 IEA
    serine-type endopeptidase activity GO:0004252 ISO
    calcium ion binding GO:0005509 IEA
    phospholipid binding GO:0005543 ISO
Biological Process
    proteolysis GO:0006508 IEA
    blood coagulation GO:0007596 IBA
    blood coagulation GO:0007596 IEA
    positive regulation of TOR signaling GO:0032008 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular space GO:0005615 IBA
 Experiment description of studies that identified F10 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for F10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Habp2  
Co-fractionation Mus musculus
2 Corin  
Co-fractionation Mus musculus
3 Tmprss7  
Co-fractionation Mus musculus
4 Ggcx  
Co-fractionation Mus musculus
5 Tmprss11f  
Co-fractionation Mus musculus
6 Tmprss6  
Co-fractionation Mus musculus
7 Tmprss4  
Co-fractionation Mus musculus
8 Fancd2  
Affinity Capture-MS Mus musculus
9 Klk1b27  
Co-fractionation Mus musculus
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