Gene description for Erbb4
Gene name	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Gene symbol	Erbb4
Other names/aliases	Her4 c-erbB-4
Species	Mus musculus
Database cross references - Erbb4
ExoCarta	ExoCarta_13869
Vesiclepedia	VP_13869
Entrez Gene	13869
UniProt	Q61527
Erbb4 identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Erbb4

Molecular Function     transcription cis-regulatory region binding GO:0000976 IEA     transcription cis-regulatory region binding GO:0000976 ISO     protein tyrosine kinase activity GO:0004713 ISO     transmembrane receptor protein tyrosine kinase activity GO:0004714 IBA     transmembrane receptor protein tyrosine kinase activity GO:0004714 IDA     transmembrane receptor protein tyrosine kinase activity GO:0004714 ISO     transmembrane receptor protein tyrosine kinase activity GO:0004714 ISS     GPI-linked ephrin receptor activity GO:0005004 IEA     transmembrane-ephrin receptor activity GO:0005005 IEA     epidermal growth factor receptor activity GO:0005006 IGI     fibroblast growth factor receptor activity GO:0005007 IEA     hepatocyte growth factor receptor activity GO:0005008 IEA     insulin receptor activity GO:0005009 IEA     insulin-like growth factor receptor activity GO:0005010 IEA     macrophage colony-stimulating factor receptor activity GO:0005011 IEA     platelet-derived growth factor alpha-receptor activity GO:0005018 IEA     platelet-derived growth factor beta-receptor activity GO:0005019 IEA     stem cell factor receptor activity GO:0005020 IEA     vascular endothelial growth factor receptor activity GO:0005021 IEA     epidermal growth factor receptor binding GO:0005154 IBA     epidermal growth factor receptor binding GO:0005154 IEA     epidermal growth factor receptor binding GO:0005154 ISO     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     boss receptor activity GO:0008288 IEA     histone H3Y41 kinase activity GO:0035401 IEA     placental growth factor receptor activity GO:0036332 IEA     protein tyrosine kinase collagen receptor activity GO:0038062 IEA     neuregulin receptor activity GO:0038131 IDA     neuregulin receptor activity GO:0038131 IMP     neuregulin receptor activity GO:0038131 ISO     neuregulin binding GO:0038132 ISO     protein homodimerization activity GO:0042803 IEA     protein homodimerization activity GO:0042803 ISO     GABA receptor binding GO:0050811 IDA     brain-derived neurotrophic factor receptor activity GO:0060175 IEA     histone H2AXY142 kinase activity GO:0140801 IEA Biological Process     neural crest cell migration GO:0001755 IMP     chromatin remodeling GO:0006338 IEA     signal transduction GO:0007165 ISO     cell surface receptor signaling pathway GO:0007166 IDA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 ISO     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 ISS     epidermal growth factor receptor signaling pathway GO:0007173 IEA     cell surface receptor signaling pathway via JAK-STAT GO:0007259 IMP     multicellular organism development GO:0007275 IBA     nervous system development GO:0007399 IMP     synapse assembly GO:0007416 IDA     synapse assembly GO:0007416 IMP     heart development GO:0007507 IMP     lactation GO:0007595 IMP     lactation GO:0007595 ISO     positive regulation of cell population proliferation GO:0008284 IBA     positive regulation of cell population proliferation GO:0008284 ISO     positive regulation of cell population proliferation GO:0008284 ISS     negative regulation of cell population proliferation GO:0008285 ISO     negative regulation of cell population proliferation GO:0008285 ISS     insulin receptor signaling pathway GO:0008286 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 IEA     embryonic pattern specification GO:0009880 IMP     negative regulation of muscle cell apoptotic process GO:0010656 ISO     cell migration GO:0016477 ISO     cell migration GO:0016477 ISS     peptidyl-tyrosine phosphorylation GO:0018108 ISO     peptidyl-tyrosine phosphorylation GO:0018108 ISS     central nervous system morphogenesis GO:0021551 IMP     olfactory bulb interneuron differentiation GO:0021889 IMP     neurogenesis GO:0022008 IBA     regulation of cell migration GO:0030334 IMP     positive regulation of cell migration GO:0030335 ISO     brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA     positive regulation of synaptic transmission, GABAergic GO:0032230 ISO     platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA     platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA     vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA     collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA     vascular endothelial growth factor signaling pathway GO:0038084 IEA     Kit signaling pathway GO:0038109 IEA     ERBB4 signaling pathway GO:0038130 IMP     ERBB4 signaling pathway GO:0038130 ISO     ERBB2-ERBB4 signaling pathway GO:0038135 IDA     ERBB2-ERBB4 signaling pathway GO:0038135 IGI     ERBB4-ERBB4 signaling pathway GO:0038138 IDA     ERBB4-ERBB4 signaling pathway GO:0038138 ISO     macrophage colony-stimulating factor signaling pathway GO:0038145 IEA     positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 IMP     positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 ISO     negative regulation of apoptotic process GO:0043066 IBA     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of apoptotic process GO:0043066 ISS     surfactant homeostasis GO:0043129 ISO     mitochondrial fragmentation involved in apoptotic process GO:0043653 ISO     mitochondrial fragmentation involved in apoptotic process GO:0043653 ISS     cell fate commitment GO:0045165 IDA     positive regulation of DNA-templated transcription GO:0045893 IMP     positive regulation of DNA-templated transcription GO:0045893 ISO     positive regulation of D-glucose import GO:0046326 ISO     positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 IMP     positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 ISO     protein autophosphorylation GO:0046777 ISO     protein autophosphorylation GO:0046777 ISS     insulin-like growth factor receptor signaling pathway GO:0048009 IEA     hepatocyte growth factor receptor signaling pathway GO:0048012 IEA     ephrin receptor signaling pathway GO:0048013 IEA     positive regulation of epithelial cell proliferation GO:0050679 ISO     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IGI     positive regulation of cardiac muscle cell proliferation GO:0060045 IMP     synapse maturation GO:0060074 ISO     mammary gland epithelial cell differentiation GO:0060644 IMP     mammary gland alveolus development GO:0060749 IMP     cardiac muscle tissue regeneration GO:0061026 IMP     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS     positive regulation of phospholipid biosynthetic process GO:0071073 ISO     cellular response to epidermal growth factor stimulus GO:0071364 IDA     establishment of planar polarity involved in nephron morphogenesis GO:0072046 IMP     neurotransmitter receptor localization to postsynaptic specialization membrane GO:0099645 IDA     neurotransmitter receptor localization to postsynaptic specialization membrane GO:0099645 IMP     positive regulation of protein localization to cell surface GO:2000010 IGI Subcellular Localization     nucleus GO:0005634 IEA     nucleus GO:0005634 ISO     mitochondrion GO:0005739 IEA     mitochondrion GO:0005739 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     caveola GO:0005901 ISO     basal plasma membrane GO:0009925 IBA     basolateral plasma membrane GO:0016323 IEA     basolateral plasma membrane GO:0016323 ISO     dendrite GO:0030425 ISO     neuromuscular junction GO:0031594 IDA     neuromuscular junction GO:0031594 IMP     presynaptic membrane GO:0042734 IDA     neuronal cell body GO:0043025 ISO     receptor complex GO:0043235 IBA     receptor complex GO:0043235 ISO     postsynaptic membrane GO:0045211 ISO     postsynaptic membrane GO:0045211 ISS     inhibitory synapse GO:0060077 ISO     postsynaptic density membrane GO:0098839 IDA     glutamatergic synapse GO:0098978 IDA     GABA-ergic synapse GO:0098982 IDA     GABA-ergic synapse GO:0098982 IMP