Gene description for COL13A1
Gene name collagen, type XIII, alpha 1
Gene symbol COL13A1
Other names/aliases COLXIIIA1
Species Homo sapiens
 Database cross references - COL13A1
ExoCarta ExoCarta_1305
Vesiclepedia VP_1305
Entrez Gene 1305
HGNC 2190
MIM 120350
UniProt Q5TAT6  
 COL13A1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for COL13A1
Molecular Function
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IBA
    heparin binding GO:0008201 IDA
    extracellular matrix structural constituent conferring tensile strength GO:0030020 IBA
    extracellular matrix structural constituent conferring tensile strength GO:0030020 RCA
Biological Process
    skeletal system development GO:0001501 IBA
    morphogenesis of a branching structure GO:0001763 IBA
    morphogenesis of a branching structure GO:0001763 ISS
    endochondral ossification GO:0001958 ISS
    cell-matrix adhesion GO:0007160 IBA
    cell-matrix adhesion GO:0007160 IPI
    cell differentiation GO:0030154 IEA
    extracellular matrix organization GO:0030198 IBA
    cell-cell adhesion GO:0098609 IBA
    cell-cell adhesion GO:0098609 IEP
Subcellular Localization
    extracellular region GO:0005576 TAS
    collagen type IX trimer GO:0005594 IBA
    collagen type XIII trimer GO:0005600 TAS
    basement membrane GO:0005604 IBA
    extracellular space GO:0005615 IBA
    endoplasmic reticulum lumen GO:0005788 TAS
    plasma membrane GO:0005886 TAS
    cell-cell junction GO:0005911 IBA
    postsynaptic membrane GO:0045211 IEA
    collagen-containing extracellular matrix GO:0062023 HDA
 Experiment description of studies that identified COL13A1 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for COL13A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COLGALT2  
Affinity Capture-MS Homo sapiens
2 PLOD3 8985
Affinity Capture-MS Homo sapiens
3 LAIR2  
Affinity Capture-MS Homo sapiens
4 HIST1H4A 8359
Cross-Linking-MS (XL-MS) Homo sapiens
5 SYNPR  
Affinity Capture-MS Homo sapiens
6 PLOD1 5351
Affinity Capture-MS Homo sapiens
7 SOX2  
Affinity Capture-MS Homo sapiens
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